Evaluation of the Disk Diffusion Method Compared to the Microdilution Method in Susceptibility Testing of Anidulafungin against Filamentous Fungi

Susceptibility testing of anidulafungin (AFG) against 32 mold isolates showed an excellent correlation between disk diffusion (DD) and broth microdilution methods. Based on our data, a 2-μg disk of AFG and a 24-h reading time might represent the best parameters for AFG DD testing against filamentous...

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Veröffentlicht in:	Journal of Clinical Microbiology 2008-12, Vol.46 (12), p.4071-4074
Hauptverfasser:	Maida, Carmelo Massimo, Milici, Maria Eleonora, Trovato, Laura, Oliveri, Salvatore, Amodio, Emanuele, Spreghini, Elisabetta, Scalise, Giorgio, Barchiesi, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Anidulafungin Antifungal Agents - pharmacology Biological and medical sciences Echinocandins - pharmacology Fundamental and applied biological sciences. Psychology Fungi - drug effects Humans Microbial Sensitivity Tests - methods Microbiology Mycology Mycoses - microbiology
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Zusammenfassung:	Susceptibility testing of anidulafungin (AFG) against 32 mold isolates showed an excellent correlation between disk diffusion (DD) and broth microdilution methods. Based on our data, a 2-μg disk of AFG and a 24-h reading time might represent the best parameters for AFG DD testing against filamentous fungi.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.01088-08