Towards a molecular understanding of arthritis

Towards a molecular understanding of arthritis

Several different agents including free radicals, oxidizing compounds and proteases are believed to play a role in the onset of arthritis. The evidence and underlying chemistry presently available for each destructive agent are presented.

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Bibliographische Detailangaben
Veröffentlicht in:Chemistry & biology 1999-06, Vol.6 (6), p.R157-R166
Hauptverfasser: Flugge, Lisa A, Miller-Deist, Lynne A, Petillo, Peter A
Format: Artikel
Sprache:eng
Schlagworte:
Aggrecans
Arthritis - etiology
Arthritis - metabolism
Carbohydrate Sequence
Cartilage - metabolism
Extracellular Matrix Proteins
Free Radicals - metabolism
Humans
Hyaluronic Acid - chemistry
Hyaluronic Acid - metabolism
Lectins, C-Type
Metalloendopeptidases - metabolism
Molecular Sequence Data
Nitric Oxide - metabolism
Proteoglycans - chemistry
Proteoglycans - metabolism
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Beschreibung
Zusammenfassung:Several different agents including free radicals, oxidizing compounds and proteases are believed to play a role in the onset of arthritis. The evidence and underlying chemistry presently available for each destructive agent are presented.
ISSN:1074-5521
1879-1301
DOI:10.1016/S1074-5521(99)80043-X