Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats
Despite the potential use of long‐chain polyunsaturated fatty acid (LCPUFA) supplementation to promote growth and neural development of the infant, little is known about potential harmful effects of the supplementation. The present study determined whether supplementation with arachidonic acid (AA)...
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| Veröffentlicht in: | Lipids 1999-05, Vol.34 (5), p.483-488 |
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| description | Despite the potential use of long‐chain polyunsaturated fatty acid (LCPUFA) supplementation to promote growth and neural development of the infant, little is known about potential harmful effects of the supplementation. The present study determined whether supplementation with arachidonic acid (AA) and/or docosahexaenoic acid (DHA) in rat milk formula (RMF) affects saturation of pulmonary surfactant phospholipids (PL). Beginning at 7 d of age, infant rats were artificially fed for 10 d with RMF supplemented with AA at 0, 0.5, and 1.0% of total fatty acid, or supplemented with DHA at 0, 0.5, and 1.0%, or cosupplemented with AA and DHA at levels of 0∶0, 0.5∶0.3, and 1.0∶0.6% of the fat blend. Lung tissue PL contained 43 weight percent palmitate (16∶0) of total fatty acids in infant rats fed the unsupplemented RMF. The supplementation with AA at both 0.5 and 1.0% decreased the weight percentage of 16∶0 and stearate (18∶0), indicating a decrease in saturation of PL. The observed decreases were accompanied by increases in AA and linoleic acid (18∶2n−6). Surfactant phosphatidylcholine (PC) consisted of 71 weight percent 16∶0 in the unsupplemented group, and this highly saturated PC was not altered by the cosupplementation with AA and DHA although there was a slight increase in DHA. Similarly, the cosupplementation did not change fatty acid composition of surfactant PL when compared with the unsupplemented group. The cosupplementation slightly decreased the weight percentage of 16∶0 with a proportional increase in 18∶0 leading to an unchanged weight percentage of total saturated fatty acids. These results suggest that, unlike lung tissue PL, the composition of saturated fatty acids in surfactant PL, particularly PC, is resistant to change by dietary AA and DHA supplementation. This, together with the unchanged concentration of total fatty acids in surfactant PC, indicates that LCPUFA cosupplementation causes no effect on pulmonary surfactant. |
| doi_str_mv | 10.1007/s11745-999-0388-2 |
| format | Article |
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The present study determined whether supplementation with arachidonic acid (AA) and/or docosahexaenoic acid (DHA) in rat milk formula (RMF) affects saturation of pulmonary surfactant phospholipids (PL). Beginning at 7 d of age, infant rats were artificially fed for 10 d with RMF supplemented with AA at 0, 0.5, and 1.0% of total fatty acid, or supplemented with DHA at 0, 0.5, and 1.0%, or cosupplemented with AA and DHA at levels of 0∶0, 0.5∶0.3, and 1.0∶0.6% of the fat blend. Lung tissue PL contained 43 weight percent palmitate (16∶0) of total fatty acids in infant rats fed the unsupplemented RMF. The supplementation with AA at both 0.5 and 1.0% decreased the weight percentage of 16∶0 and stearate (18∶0), indicating a decrease in saturation of PL. The observed decreases were accompanied by increases in AA and linoleic acid (18∶2n−6). Surfactant phosphatidylcholine (PC) consisted of 71 weight percent 16∶0 in the unsupplemented group, and this highly saturated PC was not altered by the cosupplementation with AA and DHA although there was a slight increase in DHA. Similarly, the cosupplementation did not change fatty acid composition of surfactant PL when compared with the unsupplemented group. The cosupplementation slightly decreased the weight percentage of 16∶0 with a proportional increase in 18∶0 leading to an unchanged weight percentage of total saturated fatty acids. These results suggest that, unlike lung tissue PL, the composition of saturated fatty acids in surfactant PL, particularly PC, is resistant to change by dietary AA and DHA supplementation. This, together with the unchanged concentration of total fatty acids in surfactant PC, indicates that LCPUFA cosupplementation causes no effect on pulmonary surfactant.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-999-0388-2</identifier><identifier>PMID: 10380120</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Animals ; Animals, Newborn ; Arachidonic Acid - administration & dosage ; Arachidonic Acid - analysis ; Arachidonic Acid - pharmacology ; Body Weight ; Diet ; dietary fat ; Dietary Fats - administration & dosage ; Dietary Fats - analysis ; Dietary Fats - pharmacology ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - analysis ; Docosahexaenoic Acids - pharmacology ; Fatty acids ; Female ; infant formulas ; Infants ; Lung - metabolism ; Milk - chemistry ; Nutrition ; Phospholipids - metabolism ; Polyunsaturated fatty acids ; Pregnancy ; Pulmonary Surfactants - metabolism ; Rats ; Rats, Sprague-Dawley ; Rodents ; Surfactants</subject><ispartof>Lipids, 1999-05, Vol.34 (5), p.483-488</ispartof><rights>1999 American Oil Chemists' Society (AOCS)</rights><rights>AOCS Press 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3963-bf67628ae72674bec0d76b8106a49aa54c24b6394e83ac04714bdf0c2acbf4c33</citedby><cites>FETCH-LOGICAL-c3963-bf67628ae72674bec0d76b8106a49aa54c24b6394e83ac04714bdf0c2acbf4c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-999-0388-2$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-999-0388-2$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10380120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Y.Y</creatorcontrib><creatorcontrib>Whitelock, K.A</creatorcontrib><creatorcontrib>Yeh, S.M</creatorcontrib><creatorcontrib>Lien, E.L</creatorcontrib><title>Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Despite the potential use of long‐chain polyunsaturated fatty acid (LCPUFA) supplementation to promote growth and neural development of the infant, little is known about potential harmful effects of the supplementation. The present study determined whether supplementation with arachidonic acid (AA) and/or docosahexaenoic acid (DHA) in rat milk formula (RMF) affects saturation of pulmonary surfactant phospholipids (PL). Beginning at 7 d of age, infant rats were artificially fed for 10 d with RMF supplemented with AA at 0, 0.5, and 1.0% of total fatty acid, or supplemented with DHA at 0, 0.5, and 1.0%, or cosupplemented with AA and DHA at levels of 0∶0, 0.5∶0.3, and 1.0∶0.6% of the fat blend. Lung tissue PL contained 43 weight percent palmitate (16∶0) of total fatty acids in infant rats fed the unsupplemented RMF. The supplementation with AA at both 0.5 and 1.0% decreased the weight percentage of 16∶0 and stearate (18∶0), indicating a decrease in saturation of PL. The observed decreases were accompanied by increases in AA and linoleic acid (18∶2n−6). Surfactant phosphatidylcholine (PC) consisted of 71 weight percent 16∶0 in the unsupplemented group, and this highly saturated PC was not altered by the cosupplementation with AA and DHA although there was a slight increase in DHA. Similarly, the cosupplementation did not change fatty acid composition of surfactant PL when compared with the unsupplemented group. The cosupplementation slightly decreased the weight percentage of 16∶0 with a proportional increase in 18∶0 leading to an unchanged weight percentage of total saturated fatty acids. These results suggest that, unlike lung tissue PL, the composition of saturated fatty acids in surfactant PL, particularly PC, is resistant to change by dietary AA and DHA supplementation. This, together with the unchanged concentration of total fatty acids in surfactant PC, indicates that LCPUFA cosupplementation causes no effect on pulmonary surfactant.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Arachidonic Acid - administration & dosage</subject><subject>Arachidonic Acid - analysis</subject><subject>Arachidonic Acid - pharmacology</subject><subject>Body Weight</subject><subject>Diet</subject><subject>dietary fat</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - analysis</subject><subject>Dietary Fats - pharmacology</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - analysis</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Fatty acids</subject><subject>Female</subject><subject>infant formulas</subject><subject>Infants</subject><subject>Lung - metabolism</subject><subject>Milk - chemistry</subject><subject>Nutrition</subject><subject>Phospholipids - metabolism</subject><subject>Polyunsaturated fatty acids</subject><subject>Pregnancy</subject><subject>Pulmonary Surfactants - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Surfactants</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFksFuFSEUhonR2NvqA7hR4sLdKAzMAEvTam1yE020a3KGAS_NDFyBSXufwZeWyXRh3LgiwPd_4eQHoVeUvKeEiA-ZUsG7RinVECZl0z5BO9p1slGMiKdoR0jLG94SeobOc76rW8pV9xyd0YoT2pId-n3lbYF0wnk5Hic721Cg-BjwvS8HDAnMwY8xeIMhjHiMJmY42AewIa5nxo8ZHyDjELF1zpqCa_a4THMMmzU5MAVCwT5UXfHOGw_TdMLJQrJjPXbrbYKSX6BnDqZsXz6uF-j286cfl1-a_dfrm8uP-8Yw1bNmcL3oWwlWtL3ggzVkFP0gKemBK4COm5YPPVPcSgaGcEH5MDpiWjCD44axC_Ru8x5T_LXYXPTss7HTBMHGJeteSc6F6Cv49h_wLi4p1LdpKSVlHe1EhegGmRRzTtbpY_JzHV5Totea9FaTrjXptSbd1szrR_EyzHb8K7H1UgGxAfd-sqf_G_X-5tsV4XId7s2WdBA1_Ew-69vv9Qsw0qpqJor9AW0QqiA</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>Yeh, Y.Y</creator><creator>Whitelock, K.A</creator><creator>Yeh, S.M</creator><creator>Lien, E.L</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>199905</creationdate><title>Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats</title><author>Yeh, Y.Y ; Whitelock, K.A ; Yeh, S.M ; Lien, E.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3963-bf67628ae72674bec0d76b8106a49aa54c24b6394e83ac04714bdf0c2acbf4c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Arachidonic Acid - administration & dosage</topic><topic>Arachidonic Acid - analysis</topic><topic>Arachidonic Acid - pharmacology</topic><topic>Body Weight</topic><topic>Diet</topic><topic>dietary fat</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - analysis</topic><topic>Dietary Fats - pharmacology</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - analysis</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Fatty acids</topic><topic>Female</topic><topic>infant formulas</topic><topic>Infants</topic><topic>Lung - metabolism</topic><topic>Milk - chemistry</topic><topic>Nutrition</topic><topic>Phospholipids - metabolism</topic><topic>Polyunsaturated fatty acids</topic><topic>Pregnancy</topic><topic>Pulmonary Surfactants - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Y.Y</creatorcontrib><creatorcontrib>Whitelock, K.A</creatorcontrib><creatorcontrib>Yeh, S.M</creatorcontrib><creatorcontrib>Lien, E.L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Y.Y</au><au>Whitelock, K.A</au><au>Yeh, S.M</au><au>Lien, E.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1999-05</date><risdate>1999</risdate><volume>34</volume><issue>5</issue><spage>483</spage><epage>488</epage><pages>483-488</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Despite the potential use of long‐chain polyunsaturated fatty acid (LCPUFA) supplementation to promote growth and neural development of the infant, little is known about potential harmful effects of the supplementation. The present study determined whether supplementation with arachidonic acid (AA) and/or docosahexaenoic acid (DHA) in rat milk formula (RMF) affects saturation of pulmonary surfactant phospholipids (PL). Beginning at 7 d of age, infant rats were artificially fed for 10 d with RMF supplemented with AA at 0, 0.5, and 1.0% of total fatty acid, or supplemented with DHA at 0, 0.5, and 1.0%, or cosupplemented with AA and DHA at levels of 0∶0, 0.5∶0.3, and 1.0∶0.6% of the fat blend. Lung tissue PL contained 43 weight percent palmitate (16∶0) of total fatty acids in infant rats fed the unsupplemented RMF. The supplementation with AA at both 0.5 and 1.0% decreased the weight percentage of 16∶0 and stearate (18∶0), indicating a decrease in saturation of PL. The observed decreases were accompanied by increases in AA and linoleic acid (18∶2n−6). Surfactant phosphatidylcholine (PC) consisted of 71 weight percent 16∶0 in the unsupplemented group, and this highly saturated PC was not altered by the cosupplementation with AA and DHA although there was a slight increase in DHA. Similarly, the cosupplementation did not change fatty acid composition of surfactant PL when compared with the unsupplemented group. The cosupplementation slightly decreased the weight percentage of 16∶0 with a proportional increase in 18∶0 leading to an unchanged weight percentage of total saturated fatty acids. These results suggest that, unlike lung tissue PL, the composition of saturated fatty acids in surfactant PL, particularly PC, is resistant to change by dietary AA and DHA supplementation. This, together with the unchanged concentration of total fatty acids in surfactant PC, indicates that LCPUFA cosupplementation causes no effect on pulmonary surfactant.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>10380120</pmid><doi>10.1007/s11745-999-0388-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Lipids, 1999-05, Vol.34 (5), p.483-488 |
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| subjects | Animals Animals, Newborn Arachidonic Acid - administration & dosage Arachidonic Acid - analysis Arachidonic Acid - pharmacology Body Weight Diet dietary fat Dietary Fats - administration & dosage Dietary Fats - analysis Dietary Fats - pharmacology Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - analysis Docosahexaenoic Acids - pharmacology Fatty acids Female infant formulas Infants Lung - metabolism Milk - chemistry Nutrition Phospholipids - metabolism Polyunsaturated fatty acids Pregnancy Pulmonary Surfactants - metabolism Rats Rats, Sprague-Dawley Rodents Surfactants |
| title | Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats |
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