Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria

A study was conducted to determine the effect of highly purified hyperforin on the growth of various bacteria. It was determined that oral administration of hyperforin-containing extract of St. John's wort was well tolerated and resulted in serum levels of hyperforin up to 500 ng/mL, which supp...

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Veröffentlicht in:	The Lancet (British edition) 1999-06, Vol.353 (9170), p.2129-2129
Hauptverfasser:	Schempp, Christoph M, Pelz, Klaus, Wittmer, Annette, Schöpf, Erwin, Simon, Jan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Bacterial Infections - drug therapy Biological and medical sciences Bridged Bicyclo Compounds Drug Resistance, Microbial Drug therapy Ericales - therapeutic use Gram-Positive Bacteria Herbal medicine Herbs Humans Medical research Medical sciences Miscellaneous. Antibiotics with multiple activities Pharmacology. Drug treatments Phloroglucinol - analogs & derivatives Phytotherapy Plant Extracts - therapeutic use Staphylococcal Infections - drug therapy Staphylococcus aureus Terpenes - therapeutic use
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Zusammenfassung:	A study was conducted to determine the effect of highly purified hyperforin on the growth of various bacteria. It was determined that oral administration of hyperforin-containing extract of St. John's wort was well tolerated and resulted in serum levels of hyperforin up to 500 ng/mL, which supports potential systematic use of hyperforin.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(99)00214-7