Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids

Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2008/12/01, Vol.56(12), pp.1735-1737
Hauptverfasser: Hioki, Kazuhito, Takechi, Yumiko, Kimura, Noriyo, Tanaka, Hiroyuki, Kunishima, Munetaka
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Sprache:eng
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Zusammenfassung:Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.56.1735