Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine

1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pha...

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Veröffentlicht in:	Cellular and molecular neurobiology 1999-08, Vol.19 (4), p.427-442
Hauptverfasser:	Rotzinger, S, Bourin, M, Akimoto, Y, Coutts, R T, Baker, G B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - metabolism Antidepressive Agents - pharmacokinetics Antidepressive Agents, Second-Generation - metabolism Antidepressive Agents, Second-Generation - pharmacokinetics Clinical Trials as Topic Drug Interactions - physiology Humans
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Beschreibung
Zusammenfassung:	1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pharmacokinetic drug-drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.
ISSN:	0272-4340
DOI:	10.1023/a:1006953923305