Effect of Peumus boldus on the labeling of red blood cells and plasma proteins with Technetium-99m

Peumus boldus is used in popular medicine in Brazil. The influence of Peumus boldus on the labeling of red blood cells and plasma proteins with 99mTc was studied. Stannous chloride and 99mTc pertechnetate were incubated with blood and a tincture of Peumus boldus. Aliquots of plasma and blood cells w...

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Veröffentlicht in:	Applied radiation and isotopes 1999-08, Vol.51 (2), p.145-149
Hauptverfasser:	Wancke Reiniger, Ingrid, Fonseca de Oliveira, Joelma, Caldeira-de-Araújo, Adriano, Bernardo-Filho, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-oxidant activity Antioxidants Blood Blood Proteins - metabolism Cells Drug products Erythrocytes - metabolism Isotope Labeling - methods Medicine, Traditional Peumus boldus Plant Extracts - pharmacology Plasma proteins Proteins Radioactivity Radiopharmaceuticals - metabolism Rats Rats, Wistar Red blood cells Separation Sodium Pertechnetate Tc 99m - blood Solubility Technetium Technetium - blood Technetium-99m
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Zusammenfassung:	Peumus boldus is used in popular medicine in Brazil. The influence of Peumus boldus on the labeling of red blood cells and plasma proteins with 99mTc was studied. Stannous chloride and 99mTc pertechnetate were incubated with blood and a tincture of Peumus boldus. Aliquots of plasma and blood cells were isolated from the mixture and treated with trichloroacetic acid (TCA). After separation, analysis of the soluble and insoluble fractions showed a rapid uptake of the radioactivity by blood cells in the presence of the drug, whereas there was a slight decrease in the amount of 99mTc radioactivity in the TCA-insoluble fraction of plasma.
ISSN:	0969-8043 1872-9800
DOI:	10.1016/S0969-8043(98)00200-0