Transfer RNA modification: influence on translational frameshifting and metabolism

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471–482]. Evidence that the presence of various modified nucleosides in t...

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Veröffentlicht in:	FEBS Letters 1999-06, Vol.452 (1), p.47-51
Hauptverfasser:	Björk, Glenn R, Durand, Jérôme M.B, Hagervall, Tord G, Leipuvien≐, Ramun≐, Lundgren, Hans K, Nilsson, Kristina, Chen, Peng, Qian, Qiang, Urbonavičius, Jaunius
Format:	Artikel
Sprache:	eng
Schlagworte:	Central metabolism Frameshifting Frameshifting, Ribosomal - genetics Frameshifting, Ribosomal - physiology Modified nucleoside RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism tRNA Virulence
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Zusammenfassung:	Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471–482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/S0014-5793(99)00528-1