Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression
We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial an...
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| Veröffentlicht in: | Journal of neuroimmunology 1999-02, Vol.94 (1), p.66-73 |
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| container_title | Journal of neuroimmunology |
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| creator | Stan, Alexandru C Walter, Gerhard F Welte, Karl Schneider, Berthold Bona, Constantin A Pietsch, Torsten |
| description | We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression. |
| doi_str_mv | 10.1016/S0165-5728(98)00225-2 |
| format | Article |
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The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(98)00225-2</identifier><identifier>PMID: 10376937</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Astrocytes - chemistry ; Astrocytes - metabolism ; Astrocytes - pathology ; Biomarkers ; Brain Neoplasms - immunology ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cell Differentiation - immunology ; Densitometry ; Differentiation ; Disease Progression ; Female ; G-CSF ; Glial Fibrillary Acidic Protein - analysis ; Glial Fibrillary Acidic Protein - biosynthesis ; Glioblastoma - immunology ; Glioblastoma - metabolism ; Glioblastoma - pathology ; Glioma ; Granulocyte Colony-Stimulating Factor - analysis ; Granulocyte Colony-Stimulating Factor - biosynthesis ; Granulocyte Colony-Stimulating Factor - immunology ; Humans ; Male ; Middle Aged ; Oligodendroglia - chemistry ; Oligodendroglia - metabolism ; Oligodendroglia - pathology ; Oligodendroglioma - immunology ; Oligodendroglioma - metabolism ; Oligodendroglioma - pathology ; Recurrence</subject><ispartof>Journal of neuroimmunology, 1999-02, Vol.94 (1), p.66-73</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-37bd7465ee56d3bf5e286e103c8b398a6c7fd5fc99afc234d345564dc3a25fd73</citedby><cites>FETCH-LOGICAL-c392t-37bd7465ee56d3bf5e286e103c8b398a6c7fd5fc99afc234d345564dc3a25fd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-5728(98)00225-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10376937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stan, Alexandru C</creatorcontrib><creatorcontrib>Walter, Gerhard F</creatorcontrib><creatorcontrib>Welte, Karl</creatorcontrib><creatorcontrib>Schneider, Berthold</creatorcontrib><creatorcontrib>Bona, Constantin A</creatorcontrib><creatorcontrib>Pietsch, Torsten</creatorcontrib><title>Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Astrocytes - chemistry</subject><subject>Astrocytes - metabolism</subject><subject>Astrocytes - pathology</subject><subject>Biomarkers</subject><subject>Brain Neoplasms - immunology</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Differentiation - immunology</subject><subject>Densitometry</subject><subject>Differentiation</subject><subject>Disease Progression</subject><subject>Female</subject><subject>G-CSF</subject><subject>Glial Fibrillary Acidic Protein - analysis</subject><subject>Glial Fibrillary Acidic Protein - biosynthesis</subject><subject>Glioblastoma - immunology</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - pathology</subject><subject>Glioma</subject><subject>Granulocyte Colony-Stimulating Factor - analysis</subject><subject>Granulocyte Colony-Stimulating Factor - biosynthesis</subject><subject>Granulocyte Colony-Stimulating Factor - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oligodendroglia - chemistry</subject><subject>Oligodendroglia - metabolism</subject><subject>Oligodendroglia - pathology</subject><subject>Oligodendroglioma - immunology</subject><subject>Oligodendroglioma - metabolism</subject><subject>Oligodendroglioma - pathology</subject><subject>Recurrence</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoTs_oT1CyEmdRmkelKrWSYRgfMOBCXYd0ctNGUkmbpEYb_PGmpxpxN3DJ3XznHnIOQi8oeUMJHd5-aY_oxMjk60leEsKY6NgjtKFyZJ3sGX2MNv-QM3Reyg9CqOD99BSdUcLHYeLjBv25-b3PUIpPESeHd1nHJSRzqIBNCikeulL9vARdfdxhp01NGfuIM5glZ4gV74LXAddlTrlg3ybeQS4QDu1AI5oSLP7l6_eVwfucdifHZ-iJ06HA89O-QN_e33y9_tjdfv7w6frqtjN8YrXj49aO_SAAxGD51glgcoD2ByO3fJJ6MKOzwplp0s4w3lveCzH01nDNhLMjv0Cv1rvN--cCparZFwMh6AhpKWqYJGeU9A-CdKRcDPIIihU0OZWSwal99rPOB0WJOvaj7vtRx_DVJNV9P4o13cuTwbKdwf6nWgtpwLsVgJbHnYesivEQDVjfIq_KJv-AxV9JPKPN</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Stan, Alexandru C</creator><creator>Walter, Gerhard F</creator><creator>Welte, Karl</creator><creator>Schneider, Berthold</creator><creator>Bona, Constantin A</creator><creator>Pietsch, Torsten</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression</title><author>Stan, Alexandru C ; Walter, Gerhard F ; Welte, Karl ; Schneider, Berthold ; Bona, Constantin A ; Pietsch, Torsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-37bd7465ee56d3bf5e286e103c8b398a6c7fd5fc99afc234d345564dc3a25fd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Astrocytes - chemistry</topic><topic>Astrocytes - metabolism</topic><topic>Astrocytes - pathology</topic><topic>Biomarkers</topic><topic>Brain Neoplasms - immunology</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Differentiation - immunology</topic><topic>Densitometry</topic><topic>Differentiation</topic><topic>Disease Progression</topic><topic>Female</topic><topic>G-CSF</topic><topic>Glial Fibrillary Acidic Protein - analysis</topic><topic>Glial Fibrillary Acidic Protein - biosynthesis</topic><topic>Glioblastoma - immunology</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma - pathology</topic><topic>Glioma</topic><topic>Granulocyte Colony-Stimulating Factor - analysis</topic><topic>Granulocyte Colony-Stimulating Factor - biosynthesis</topic><topic>Granulocyte Colony-Stimulating Factor - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oligodendroglia - chemistry</topic><topic>Oligodendroglia - metabolism</topic><topic>Oligodendroglia - pathology</topic><topic>Oligodendroglioma - immunology</topic><topic>Oligodendroglioma - metabolism</topic><topic>Oligodendroglioma - pathology</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stan, Alexandru C</creatorcontrib><creatorcontrib>Walter, Gerhard F</creatorcontrib><creatorcontrib>Welte, Karl</creatorcontrib><creatorcontrib>Schneider, Berthold</creatorcontrib><creatorcontrib>Bona, Constantin A</creatorcontrib><creatorcontrib>Pietsch, Torsten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stan, Alexandru C</au><au>Walter, Gerhard F</au><au>Welte, Karl</au><au>Schneider, Berthold</au><au>Bona, Constantin A</au><au>Pietsch, Torsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>94</volume><issue>1</issue><spage>66</spage><epage>73</epage><pages>66-73</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10376937</pmid><doi>10.1016/S0165-5728(98)00225-2</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Astrocytes - chemistry Astrocytes - metabolism Astrocytes - pathology Biomarkers Brain Neoplasms - immunology Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Differentiation - immunology Densitometry Differentiation Disease Progression Female G-CSF Glial Fibrillary Acidic Protein - analysis Glial Fibrillary Acidic Protein - biosynthesis Glioblastoma - immunology Glioblastoma - metabolism Glioblastoma - pathology Glioma Granulocyte Colony-Stimulating Factor - analysis Granulocyte Colony-Stimulating Factor - biosynthesis Granulocyte Colony-Stimulating Factor - immunology Humans Male Middle Aged Oligodendroglia - chemistry Oligodendroglia - metabolism Oligodendroglia - pathology Oligodendroglioma - immunology Oligodendroglioma - metabolism Oligodendroglioma - pathology Recurrence |
| title | Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression |
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