Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression

We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial an...

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Veröffentlicht in:Journal of neuroimmunology 1999-02, Vol.94 (1), p.66-73
Hauptverfasser: Stan, Alexandru C, Walter, Gerhard F, Welte, Karl, Schneider, Berthold, Bona, Constantin A, Pietsch, Torsten
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Sprache:eng
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Zusammenfassung:We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(98)00225-2