The role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction in rabbits
We investigated the role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction using a specific type-IV phosphodiesterase inhibitor, rolipram, that inhibits the production of TNF-alpha. The body temperatures and serum iron concentrations of rabbits were measured following...
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| Veröffentlicht in: | Pflügers Archiv 1999-07, Vol.438 (2), p.218-223 |
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| description | We investigated the role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction using a specific type-IV phosphodiesterase inhibitor, rolipram, that inhibits the production of TNF-alpha. The body temperatures and serum iron concentrations of rabbits were measured following injections of lipopolysaccharide (LPS) or Staphylococcus aureus (S. aureus) with either rolipram, diclofenac sodium or the appropriate control solutions. Rolipram significantly (P |
| doi_str_mv | 10.1007/s004240050901 |
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The body temperatures and serum iron concentrations of rabbits were measured following injections of lipopolysaccharide (LPS) or Staphylococcus aureus (S. aureus) with either rolipram, diclofenac sodium or the appropriate control solutions. Rolipram significantly (P<0.05) inhibited the first phase of both LPS and Staphylococcal fever, but had no effect on the second phase. The fall in serum iron concentration was not significantly affected by the injection of rolipram together with LPS or S. aureus. These results suggest that TNF-alpha is a pyrogen that plays a role during the first phase of fever, at least. However, TNF-alpha appears not to mediate the fall in serum iron concentration during the acute phase reaction.</description><identifier>ISSN: 0031-6768</identifier><identifier>EISSN: 1432-2013</identifier><identifier>DOI: 10.1007/s004240050901</identifier><identifier>PMID: 10370109</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Acute-Phase Reaction - microbiology ; Acute-Phase Reaction - physiopathology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Bacteria ; Body Temperature ; Fever - microbiology ; Fever - physiopathology ; Iron - blood ; Lipopolysaccharides ; Male ; Pyrrolidinones - pharmacology ; Rabbits ; Rolipram ; Salmonella typhi ; Staphylococcus aureus ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>Pflügers Archiv, 1999-07, Vol.438 (2), p.218-223</ispartof><rights>Springer-Verlag Berlin Heidelberg 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-7f2aed2666a1e4610755b029463417436783236538339f963fcb8672e60d84643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10370109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mabika, M</creatorcontrib><creatorcontrib>Laburn, H</creatorcontrib><title>The role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction in rabbits</title><title>Pflügers Archiv</title><addtitle>Pflugers Arch</addtitle><description>We investigated the role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction using a specific type-IV phosphodiesterase inhibitor, rolipram, that inhibits the production of TNF-alpha. 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However, TNF-alpha appears not to mediate the fall in serum iron concentration during the acute phase reaction.</description><subject>Acute-Phase Reaction - microbiology</subject><subject>Acute-Phase Reaction - physiopathology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Bacteria</subject><subject>Body Temperature</subject><subject>Fever - microbiology</subject><subject>Fever - physiopathology</subject><subject>Iron - blood</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Pyrrolidinones - pharmacology</subject><subject>Rabbits</subject><subject>Rolipram</subject><subject>Salmonella typhi</subject><subject>Staphylococcus aureus</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkD1PwzAQhi0EoqUwsiKLAcEQOH_UdkZUUUCqYClz5CRnNVU-ip0g8e9xlQ7A5JP83Ht3DyGXDO4ZgH4IAJJLgDmkwI7IlEnBEw5MHJMpgGCJ0spMyFkIWwDg0vBTMmEgNDBIpwTXG6S-q5F2jvZD0w2etlj4LlSBOlv0nU9svdtYert-W47lHa1a6vALPbVtSfuYYIuhRxr_QkzD2FZ17Z7yNs-rPpyTE2frgBeHd0Y-lk_rxUuyen9-XTyukkIw1SfacYslV0pZhlIx0PN5DjyVSkimpVDaCC7UXBghUpcq4YrcKM1RQWmkkmJGbsbcne8-Bwx91lShwLq2LXZDyFRq4qBURPD6H7iNl7dxt8xoGTUBZxFKRmivI3h02c5XjfXfGYNsLz_7Iz_yV4fQIW-w_EWPtsUPlB57WQ</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Mabika, M</creator><creator>Laburn, H</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>The role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction in rabbits</title><author>Mabika, M ; 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The body temperatures and serum iron concentrations of rabbits were measured following injections of lipopolysaccharide (LPS) or Staphylococcus aureus (S. aureus) with either rolipram, diclofenac sodium or the appropriate control solutions. Rolipram significantly (P<0.05) inhibited the first phase of both LPS and Staphylococcal fever, but had no effect on the second phase. The fall in serum iron concentration was not significantly affected by the injection of rolipram together with LPS or S. aureus. These results suggest that TNF-alpha is a pyrogen that plays a role during the first phase of fever, at least. However, TNF-alpha appears not to mediate the fall in serum iron concentration during the acute phase reaction.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>10370109</pmid><doi>10.1007/s004240050901</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute-Phase Reaction - microbiology Acute-Phase Reaction - physiopathology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bacteria Body Temperature Fever - microbiology Fever - physiopathology Iron - blood Lipopolysaccharides Male Pyrrolidinones - pharmacology Rabbits Rolipram Salmonella typhi Staphylococcus aureus Tumor Necrosis Factor-alpha - physiology |
| title | The role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction in rabbits |
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