The role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction in rabbits

We investigated the role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction using a specific type-IV phosphodiesterase inhibitor, rolipram, that inhibits the production of TNF-alpha. The body temperatures and serum iron concentrations of rabbits were measured following...

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Veröffentlicht in:	Pflügers Archiv 1999-07, Vol.438 (2), p.218-223
Hauptverfasser:	Mabika, M, Laburn, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - microbiology Acute-Phase Reaction - physiopathology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bacteria Body Temperature Fever - microbiology Fever - physiopathology Iron - blood Lipopolysaccharides Male Pyrrolidinones - pharmacology Rabbits Rolipram Salmonella typhi Staphylococcus aureus Tumor Necrosis Factor-alpha - physiology
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Zusammenfassung:	We investigated the role of tumour necrosis factor-alpha (TNF-alpha) in fever and the acute phase reaction using a specific type-IV phosphodiesterase inhibitor, rolipram, that inhibits the production of TNF-alpha. The body temperatures and serum iron concentrations of rabbits were measured following injections of lipopolysaccharide (LPS) or Staphylococcus aureus (S. aureus) with either rolipram, diclofenac sodium or the appropriate control solutions. Rolipram significantly (P
ISSN:	0031-6768 1432-2013
DOI:	10.1007/s004240050901