Procalcitonin as a Useful Marker of Infection in Hemato-oncological Patients with Fever

Background: The diagnostic utility of procalcitonin (PCT) and C-reactive protein (CRP) to discriminate between infective fever and fever due to inflammation was assessed in hemato-oncological patients treated with aggressive chemotherapy. Patients and Methods: Values of PCT and PCR measured on days...

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Veröffentlicht in:	Anticancer research 2008-09, Vol.28 (5B), p.3061-3065
Hauptverfasser:	SANDRI, Maria T, PASSERINI, Rita, LEON, Maria E, PECCATORI, Fedro A, ZORZINO, Laura, SALVATICI, Michela, RIGGIO, Daniela, CASSATELLA, Cristina, CINIERI, Saverio, MARTINELLI, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Bacteremia - blood Bacteremia - complications Bacteremia - microbiology Biological and medical sciences C-Reactive Protein - metabolism Calcitonin - blood Calcitonin Gene-Related Peptide Female Fever - blood Fever - complications Fever - microbiology Gram-Negative Bacteria - isolation & purification Gram-Negative Bacterial Infections - blood Gram-Negative Bacterial Infections - complications Gram-Positive Bacterial Infections - blood Gram-Positive Bacterial Infections - complications Gram-Positive Cocci - isolation & purification Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Neoplasms - blood Neoplasms - complications Neoplasms - drug therapy Neoplasms - microbiology Other diseases. Hematologic involvement in other diseases Protein Precursors - blood Tumors Young Adult
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Zusammenfassung:	Background: The diagnostic utility of procalcitonin (PCT) and C-reactive protein (CRP) to discriminate between infective fever and fever due to inflammation was assessed in hemato-oncological patients treated with aggressive chemotherapy. Patients and Methods: Values of PCT and PCR measured on days -1, 0, 1, 3 and 5 of onset of fever were analyzed using longitudinal regression analysis. Of 236 febrile episodes in 166 patients, 39 were due to bacteremia, 62 to other infections and 135 were classified as fever of unknown origin. Results: PCT concentration increased early only in bacteremia and other infections (p
ISSN:	0250-7005 1791-7530