Tumour necrosis factor, a key role in obesity?

Tumour necrosis factor, a key role in obesity?

Tumour necrosis factor-α (TNF) is a pleiotropic cytokine involved in many metabolic responses in both normal and pathophysiological states. In spite of the fact that this cytokine (also known as “cachectin”) has been related to many of the metabolic abnormalities associated with cachexia, recent stu...

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Veröffentlicht in:FEBS Letters 1999-05, Vol.451 (3), p.215-219
Hauptverfasser: Bulló-Bonet, M., García-Lorda, P., López-Soriano, F.J., Argilés, J.M., Salas-Salvadó, J.
Format: Artikel
Sprache:eng
Schlagworte:
Adipose tissue
Adipose Tissue - metabolism
Energy Metabolism
Humans
Insulin resistance
Obesity
Obesity - metabolism
TNF
Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:Tumour necrosis factor-α (TNF) is a pleiotropic cytokine involved in many metabolic responses in both normal and pathophysiological states. In spite of the fact that this cytokine (also known as “cachectin”) has been related to many of the metabolic abnormalities associated with cachexia, recent studies suggest that TNF may also have a central role in obesity modulating energy expenditure, fat deposition and insulin resistance. This review deals with the role of TNF in the control of fat mass and obesity.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00540-2