Effect of nitric oxide predilution on inhaled nitrogen dioxide concentrations

We examined the possibility that predilution of a concentrated nitric oxide (NO) source with nitrogen, before contact with oxygen, can reduce the inspired nitrogen dioxide (NO2) concentration during administration of nitric oxide. A Manley Blease and a Siemens Servo 900 C ventilator delivered 10, 20...

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Veröffentlicht in:	Anaesthesia 1999-03, Vol.54 (3), p.220-225
Hauptverfasser:	Foubert, L., Mareels, K., den Blauwen, N., Herregods, L., Rolly, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiovascular system Drug Administration Schedule Gases, nonanaesthetic nitric oxide Humans Medical sciences Models, Chemical Nitric Oxide - administration & dosage Nitric Oxide - chemistry Nitrogen - chemistry Nitrogen Dioxide - administration & dosage Nitrogen Dioxide - chemistry Oxidation-Reduction Pharmacology. Drug treatments Vasodilator Agents - administration & dosage Vasodilator Agents - chemistry Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	We examined the possibility that predilution of a concentrated nitric oxide (NO) source with nitrogen, before contact with oxygen, can reduce the inspired nitrogen dioxide (NO2) concentration during administration of nitric oxide. A Manley Blease and a Siemens Servo 900 C ventilator delivered 10, 20, 40, 60 and 80 parts per million (ppm) NO using an NO source of 1000, 400 and 200 ppm. With the Manley Blease system, predilution from 1000 to 200 ppm NO reduced the inhaled NO2 concentration from 0.14 to 0.05 ppm (p
ISSN:	0003-2409 1365-2044
DOI:	10.1046/j.1365-2044.1999.00702.x