Heterogeneous Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and Phosphine-Modified Iridium Catalysts

Heterogeneous Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and Phosphine-Modified Iridium Catalysts

Catalyst support: The first highly enantioselective heterogeneous hydrogenation of aromatic ketones catalyzed by Ir/SiO2 stabilized with Ph3P and modified by a chiral diamine derived from a cinchona alkaloid is described (see scheme). The reaction can be employed for the reduction of a broad range o...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (48), p.9240-9244
Hauptverfasser: Jiang, He-yan, Yang, Chao-fen, Li, Chun, Fu, Hai-yan, Chen, Hua, Li, Rui-xiang, Li, Xian-jun
Format: Artikel
Sprache:eng
Schlagworte:
alkaloids
asymmetric catalysis
iridium
ketones
supported catalysts
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Zusammenfassung:Catalyst support: The first highly enantioselective heterogeneous hydrogenation of aromatic ketones catalyzed by Ir/SiO2 stabilized with Ph3P and modified by a chiral diamine derived from a cinchona alkaloid is described (see scheme). The reaction can be employed for the reduction of a broad range of aromatic ketones to the corresponding alcohols with high enantioselectivity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801809