Formal Asymmetric Biocatalytic Reductive Amination
All for one: A combination of three biocatalysts (ω‐transaminase, alanine dehydrogenase, and an enzyme such as formate dehydrogenase for cofactor recycling) catalyze a cascade to achieve the asymmetric transformation of a ketone into a primary α‐chiral unprotected amine through a formal stereoselect...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2008-01, Vol.47 (48), p.9337-9340 |
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| container_issue | 48 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 47 |
| creator | Koszelewski, Dominik Lavandera, Iván Clay, Dorina Guebitz, Georg M Rozzell, David Kroutil, Wolfgang |
| description | All for one: A combination of three biocatalysts (ω‐transaminase, alanine dehydrogenase, and an enzyme such as formate dehydrogenase for cofactor recycling) catalyze a cascade to achieve the asymmetric transformation of a ketone into a primary α‐chiral unprotected amine through a formal stereoselective reductive amination (see scheme). Only ammonia and the reducing agent (formate) are consumed during this reaction. |
| doi_str_mv | 10.1002/anie.200803763 |
| format | Article |
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| ispartof | Angewandte Chemie (International ed.), 2008-01, Vol.47 (48), p.9337-9340 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amination amines Amines - chemistry Amines - metabolism asymmetric catalysis Biocatalysis cascade reactions Ketones - chemistry Oxidation-Reduction reductive amination Stereoisomerism |
| title | Formal Asymmetric Biocatalytic Reductive Amination |
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