Formal Asymmetric Biocatalytic Reductive Amination

Formal Asymmetric Biocatalytic Reductive Amination

All for one: A combination of three biocatalysts (ω‐transaminase, alanine dehydrogenase, and an enzyme such as formate dehydrogenase for cofactor recycling) catalyze a cascade to achieve the asymmetric transformation of a ketone into a primary α‐chiral unprotected amine through a formal stereoselect...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (48), p.9337-9340
Hauptverfasser: Koszelewski, Dominik, Lavandera, Iván, Clay, Dorina, Guebitz, Georg M, Rozzell, David, Kroutil, Wolfgang
Format: Artikel
Sprache:eng
Schlagworte:
Amination
amines
Amines - chemistry
Amines - metabolism
asymmetric catalysis
Biocatalysis
cascade reactions
Ketones - chemistry
Oxidation-Reduction
reductive amination
Stereoisomerism
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Beschreibung
Zusammenfassung:All for one: A combination of three biocatalysts (ω‐transaminase, alanine dehydrogenase, and an enzyme such as formate dehydrogenase for cofactor recycling) catalyze a cascade to achieve the asymmetric transformation of a ketone into a primary α‐chiral unprotected amine through a formal stereoselective reductive amination (see scheme). Only ammonia and the reducing agent (formate) are consumed during this reaction.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200803763