A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma
A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile. The analytes were separated on a...
Gespeichert in:
| Veröffentlicht in: | Therapeutic drug monitoring 1999-06, Vol.21 (3), p.322-324 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 324 |
|---|---|
| container_issue | 3 |
| container_start_page | 322 |
| container_title | Therapeutic drug monitoring |
| container_volume | 21 |
| creator | SVENSSON, J.-O BRATTSTRÖM, T SÄWE, J |
| description | A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile. The analytes were separated on a C18 column with a mobile phase containing 30% acetonitrile and a 40 mm phosphoric acid buffer at pH 2.1 and measured with UV-detection at 215 nm. |
| doi_str_mv | 10.1097/00007691-199906000-00012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69817662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69817662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-d511c140380a285d901cf5e7bfba12ece93bbe2482174dd1a20d85b46419f3ad3</originalsourceid><addsrcrecordid>eNptkE1PxCAQhonRuOvqXzAcjLcqUygtx81GXZNN9KDnhgJ1MbRUaA_77-3a9eMgCSFMnpnJ-yCEgdwAEfktGU_OBSQghCB8_CXjhfQIzSGjPKFcsGM0J8BpwmjGZ-gsxveRYAUhp2gGhPKMs2yO-iWOtumcwevnzQo3pt96jWsf9uXB9bI1fohYm96Exrayt77FvsbNTvlua1rvrMJSWY1lq_-pvrlBDcG3VhtsW9w5GRt5jk5q6aK5OLwL9Hp_97JaJ5unh8fVcpMoykif6AxAASO0IDItMi0IqDozeVVXElKjjKBVZVJWpJAzrUGmRBdZxTgDUVOp6QJdT3O74D8GE_uysVEZ56ZUJRcF5JynI1hMoAo-xmDqsgu2kWFXAin3xstv4-WP8fLL-Nh6edgxVI3RfxonxSNwdQBkVNLVQbbKxl8uF2O-lH4C9MqKGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69817662</pqid></control><display><type>article</type><title>A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>SVENSSON, J.-O ; BRATTSTRÖM, T ; SÄWE, J</creator><creatorcontrib>SVENSSON, J.-O ; BRATTSTRÖM, T ; SÄWE, J</creatorcontrib><description>A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile. The analytes were separated on a C18 column with a mobile phase containing 30% acetonitrile and a 40 mm phosphoric acid buffer at pH 2.1 and measured with UV-detection at 215 nm.</description><identifier>ISSN: 0163-4356</identifier><identifier>EISSN: 1536-3694</identifier><identifier>DOI: 10.1097/00007691-199906000-00012</identifier><identifier>PMID: 10365645</identifier><identifier>CODEN: TDMODV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Analysis ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; General pharmacology ; Glucuronates - blood ; Glucuronides ; Humans ; Medical sciences ; Molecular Structure ; Mycophenolic Acid - analogs & derivatives ; Mycophenolic Acid - blood ; Pharmacology. Drug treatments ; Time Factors</subject><ispartof>Therapeutic drug monitoring, 1999-06, Vol.21 (3), p.322-324</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-d511c140380a285d901cf5e7bfba12ece93bbe2482174dd1a20d85b46419f3ad3</citedby><cites>FETCH-LOGICAL-c340t-d511c140380a285d901cf5e7bfba12ece93bbe2482174dd1a20d85b46419f3ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1793802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10365645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SVENSSON, J.-O</creatorcontrib><creatorcontrib>BRATTSTRÖM, T</creatorcontrib><creatorcontrib>SÄWE, J</creatorcontrib><title>A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma</title><title>Therapeutic drug monitoring</title><addtitle>Ther Drug Monit</addtitle><description>A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile. The analytes were separated on a C18 column with a mobile phase containing 30% acetonitrile and a 40 mm phosphoric acid buffer at pH 2.1 and measured with UV-detection at 215 nm.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>General pharmacology</subject><subject>Glucuronates - blood</subject><subject>Glucuronides</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Mycophenolic Acid - analogs & derivatives</subject><subject>Mycophenolic Acid - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><issn>0163-4356</issn><issn>1536-3694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1PxCAQhonRuOvqXzAcjLcqUygtx81GXZNN9KDnhgJ1MbRUaA_77-3a9eMgCSFMnpnJ-yCEgdwAEfktGU_OBSQghCB8_CXjhfQIzSGjPKFcsGM0J8BpwmjGZ-gsxveRYAUhp2gGhPKMs2yO-iWOtumcwevnzQo3pt96jWsf9uXB9bI1fohYm96Exrayt77FvsbNTvlua1rvrMJSWY1lq_-pvrlBDcG3VhtsW9w5GRt5jk5q6aK5OLwL9Hp_97JaJ5unh8fVcpMoykif6AxAASO0IDItMi0IqDozeVVXElKjjKBVZVJWpJAzrUGmRBdZxTgDUVOp6QJdT3O74D8GE_uysVEZ56ZUJRcF5JynI1hMoAo-xmDqsgu2kWFXAin3xstv4-WP8fLL-Nh6edgxVI3RfxonxSNwdQBkVNLVQbbKxl8uF2O-lH4C9MqKGQ</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>SVENSSON, J.-O</creator><creator>BRATTSTRÖM, T</creator><creator>SÄWE, J</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma</title><author>SVENSSON, J.-O ; BRATTSTRÖM, T ; SÄWE, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-d511c140380a285d901cf5e7bfba12ece93bbe2482174dd1a20d85b46419f3ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>General pharmacology</topic><topic>Glucuronates - blood</topic><topic>Glucuronides</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Mycophenolic Acid - analogs & derivatives</topic><topic>Mycophenolic Acid - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SVENSSON, J.-O</creatorcontrib><creatorcontrib>BRATTSTRÖM, T</creatorcontrib><creatorcontrib>SÄWE, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic drug monitoring</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SVENSSON, J.-O</au><au>BRATTSTRÖM, T</au><au>SÄWE, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma</atitle><jtitle>Therapeutic drug monitoring</jtitle><addtitle>Ther Drug Monit</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>21</volume><issue>3</issue><spage>322</spage><epage>324</epage><pages>322-324</pages><issn>0163-4356</issn><eissn>1536-3694</eissn><coden>TDMODV</coden><abstract>A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile. The analytes were separated on a C18 column with a mobile phase containing 30% acetonitrile and a 40 mm phosphoric acid buffer at pH 2.1 and measured with UV-detection at 215 nm.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10365645</pmid><doi>10.1097/00007691-199906000-00012</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4356 |
| ispartof | Therapeutic drug monitoring, 1999-06, Vol.21 (3), p.322-324 |
| issn | 0163-4356 1536-3694 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69817662 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Analysis Biological and medical sciences Chromatography, High Pressure Liquid General pharmacology Glucuronates - blood Glucuronides Humans Medical sciences Molecular Structure Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - blood Pharmacology. Drug treatments Time Factors |
| title | A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T04%3A25%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20simple%20HPLC%20method%20for%20simultaneous%20determination%20of%20mycophenolic%20acid%20and%20mycophenolic%20acid%20glucuronide%20in%20plasma&rft.jtitle=Therapeutic%20drug%20monitoring&rft.au=SVENSSON,%20J.-O&rft.date=1999-06-01&rft.volume=21&rft.issue=3&rft.spage=322&rft.epage=324&rft.pages=322-324&rft.issn=0163-4356&rft.eissn=1536-3694&rft.coden=TDMODV&rft_id=info:doi/10.1097/00007691-199906000-00012&rft_dat=%3Cproquest_cross%3E69817662%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69817662&rft_id=info:pmid/10365645&rfr_iscdi=true |