Quantitative research methods

This paper provides some ideas for improving the quality of Alzheimer disease (AD) research projects by using the appropriate quantitative methods. Statistical tests for answering research questions are presented according to the types of design used. Recently published research studies illustrate some pitfalls to avoid and issues to consider when planning research; threats posed by multiple comparisons, how to control for threats, and cautions to use in interpreting those studies that do not control for the effects of chance. Careful attention to these details will strengthen the work and thus improve the state of the science relative to the care of persons with Alzheimer disease.