Mammalian Krüppel-like transcription factors: more than just a pretty finger
The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in t...
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| Veröffentlicht in: | Trends in Biochemical Sciences 1999-06, Vol.24 (6), p.236-240 |
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| creator | Turner, Jeremy Crossley, Merlin |
| description | The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in their zinc-finger domains but differ elsewhere. Analysis of these differences is illuminating specific mechanisms by which transcription is regulated. |
| doi_str_mv | 10.1016/S0968-0004(99)01406-1 |
| format | Article |
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Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in their zinc-finger domains but differ elsewhere. Analysis of these differences is illuminating specific mechanisms by which transcription is regulated.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>DNA-Binding Proteins - physiology</subject><subject>EKLF</subject><subject>Kruppel-Like Transcription Factors</subject><subject>Krüppel</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Phylogeny</subject><subject>Repressor Proteins</subject><subject>Sequence Homology, Amino Acid</subject><subject>SP1</subject><subject>Transcription</subject><subject>Transcription Factors - physiology</subject><subject>Zinc fingers</subject><issn>0968-0004</issn><issn>1362-4326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOxDAQRS0EYpeFTwClQlAEPLHjJDQIIV5iVxRAbXntCXjJC9uLxL_R8WNkH0J0VFPMuXM1h5B9oCdAQZw-0kLkMaWUHxXFMQVORQwbZAhMJDFnidgkw19kQHa8n1EKaZal22QAlAmRp2xIJhNV16qyqonu3fdX12EVV_YNo-BU47WzXbBtE5VKh9b5s6huXb977fHZ3IdIRZ3DED6j0jYv6HbJVqkqj3vrOSLP11dPl7fx-OHm7vJiHGsOLMTTImGmFECp4pAYpjHPuBG5SdJMG4YGWMIRWJnlmoqU8jJhWBrBMw4iUcBG5HB1t3Pt-xx9kLX1GqtKNdjOvRRFDqLgaQ-mK1C71nuHpeycrZX7lEDlwqNcepQLSbIo5NKjXBQcrAvm0xrNn9RKXA-crwDs3_yw6KTXFhuNxjrUQZrW_lPxA4blgpQ</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Turner, Jeremy</creator><creator>Crossley, Merlin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Mammalian Krüppel-like transcription factors: more than just a pretty finger</title><author>Turner, Jeremy ; Crossley, Merlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-b923df6100a412d3ce874d68d257cd3ed1324e13f78c06504f23efd6474162a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>DNA-Binding Proteins - physiology</topic><topic>EKLF</topic><topic>Kruppel-Like Transcription Factors</topic><topic>Krüppel</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Phylogeny</topic><topic>Repressor Proteins</topic><topic>Sequence Homology, Amino Acid</topic><topic>SP1</topic><topic>Transcription</topic><topic>Transcription Factors - physiology</topic><topic>Zinc fingers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turner, Jeremy</creatorcontrib><creatorcontrib>Crossley, Merlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Biochemical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turner, Jeremy</au><au>Crossley, Merlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammalian Krüppel-like transcription factors: more than just a pretty finger</atitle><jtitle>Trends in Biochemical Sciences</jtitle><addtitle>Trends Biochem Sci</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>24</volume><issue>6</issue><spage>236</spage><epage>240</epage><pages>236-240</pages><issn>0968-0004</issn><eissn>1362-4326</eissn><abstract>The transcription factor SP1 contains three Krüppel-like zinc fingers. 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| fulltext | fulltext |
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| ispartof | Trends in Biochemical Sciences, 1999-06, Vol.24 (6), p.236-240 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals DNA-Binding Proteins - physiology EKLF Kruppel-Like Transcription Factors Krüppel Mice Mice, Knockout Molecular Sequence Data Multigene Family Phylogeny Repressor Proteins Sequence Homology, Amino Acid SP1 Transcription Transcription Factors - physiology Zinc fingers |
| title | Mammalian Krüppel-like transcription factors: more than just a pretty finger |
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