Mammalian Krüppel-like transcription factors: more than just a pretty finger

The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in t...

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Veröffentlicht in:	Trends in Biochemical Sciences 1999-06, Vol.24 (6), p.236-240
Hauptverfasser:	Turner, Jeremy, Crossley, Merlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals DNA-Binding Proteins - physiology EKLF Kruppel-Like Transcription Factors Krüppel Mice Mice, Knockout Molecular Sequence Data Multigene Family Phylogeny Repressor Proteins Sequence Homology, Amino Acid SP1 Transcription Transcription Factors - physiology Zinc fingers
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Beschreibung
Zusammenfassung:	The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in their zinc-finger domains but differ elsewhere. Analysis of these differences is illuminating specific mechanisms by which transcription is regulated.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(99)01406-1