Sirolimus Ameliorated Post Lung Transplant Chylothorax in Lymphangioleiomyomatosis

We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Annals of thoracic surgery 2008-12, Vol.86 (6), p.e7-e8
Hauptverfasser:	Ohara, Toshiaki, MD, Oto, Takahiro, MD, Miyoshi, Kentaro, MD, Tao, Hiroyuki, MD, Yamane, Masaomi, MD, Toyooka, Shinichi, MD, Okazaki, Megumi, RN, Date, Hiroshi, MD, Sano, Yoshifumi, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Cardiothoracic Surgery Chylothorax - drug therapy Chylothorax - etiology Chylous Ascites - drug therapy Chylous Ascites - etiology Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans Immunosuppressive Agents - therapeutic use Lung Neoplasms - diagnosis Lung Neoplasms - surgery Lung Transplantation - adverse effects Lung Transplantation - methods Lymphangioleiomyomatosis - diagnosis Lymphangioleiomyomatosis - surgery Postoperative Complications - diagnosis Postoperative Complications - drug therapy Risk Assessment Sirolimus - therapeutic use Surgery Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.
ISSN:	0003-4975 1552-6259
DOI:	10.1016/j.athoracsur.2008.07.062