Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones
The synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported. Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six co...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2008-12, Vol.18 (24), p.6462-6467 |
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| container_issue | 24 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Singh, Okram Mukherjee Singh, Sarangthem Joychandra Devi, Mutum Babita Devi, Laitonjam Nalini Singh, Nameirakpam Irabanta Lee, Sang-Gyeong |
| description | The synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported.
Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz.,
Trichoderma hammatum,
Trichoderma koningii and
Aspergillus niger. |
| doi_str_mv | 10.1016/j.bmcl.2008.10.063 |
| format | Article |
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Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz.,
Trichoderma hammatum,
Trichoderma koningii and
Aspergillus niger.</description><identifier>ISSN: 0960-894X</identifier><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3405</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmcl.2008.10.063</identifier><identifier>PMID: 18977139</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal activity ; Antifungal agents ; Antifungal Agents - chemical synthesis ; Antifungal Agents - pharmacology ; Aspergillus niger ; Aspergillus niger - metabolism ; Biological and medical sciences ; Catalysis ; Chemistry, Pharmaceutical - methods ; Copper - chemistry ; Dihydropyrimidine ; Drug Design ; In Vitro Techniques ; Medical sciences ; Microbial Sensitivity Tests ; Models, Chemical ; Pharmacology. Drug treatments ; Pyrimidinones - chemical synthesis ; Pyrimidinones - pharmacology ; Solvent-free ; Solvents - chemistry ; Time Factors ; Trichoderma - metabolism ; Trichoderma koningii</subject><ispartof>Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6462-6467</ispartof><rights>2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-48069a7bb3cf9209e5be3c0abc96ed80b7182824bba68ba2aa3a4f87d4c1048c3</citedby><cites>FETCH-LOGICAL-c415t-48069a7bb3cf9209e5be3c0abc96ed80b7182824bba68ba2aa3a4f87d4c1048c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X08012663$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20919033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18977139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Okram Mukherjee</creatorcontrib><creatorcontrib>Singh, Sarangthem Joychandra</creatorcontrib><creatorcontrib>Devi, Mutum Babita</creatorcontrib><creatorcontrib>Devi, Laitonjam Nalini</creatorcontrib><creatorcontrib>Singh, Nameirakpam Irabanta</creatorcontrib><creatorcontrib>Lee, Sang-Gyeong</creatorcontrib><title>Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem Lett</addtitle><description>The synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported.
Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz.,
Trichoderma hammatum,
Trichoderma koningii and
Aspergillus niger.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - pharmacology</subject><subject>Aspergillus niger</subject><subject>Aspergillus niger - metabolism</subject><subject>Biological and medical sciences</subject><subject>Catalysis</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Copper - chemistry</subject><subject>Dihydropyrimidine</subject><subject>Drug Design</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Models, Chemical</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrimidinones - chemical synthesis</subject><subject>Pyrimidinones - pharmacology</subject><subject>Solvent-free</subject><subject>Solvents - chemistry</subject><subject>Time Factors</subject><subject>Trichoderma - metabolism</subject><subject>Trichoderma koningii</subject><issn>0960-894X</issn><issn>0968-0896</issn><issn>1464-3405</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7uzqH_AgfdFbj5XudHcCXmRRV1jw4AfeQiWpdjP0JGPSPTD_3jQz6E1PBVVPvVQ9jL3gsOXA-ze7rdnbadsAyNLYQt8-YhsuelG3ArrHbAOqh1oq8eOKXee8A-AChHjKrrhUw8BbtWHfv5zC_EDZ5wqDq3yojn5OsaIjTgvOPoYqjlUhynj24xJ-4lShnX3BPOV16PzDyaV4OCW_986HGCg_Y09GnDI9v9Qb9u3D-6-3d_X954-fbt_d11bwbq6FhF7hYExrR9WAos5QawGNVT05CWbgspGNMAZ7abBBbFGMcnDCchDStjfs9Tn3kOKvhfKs9z5bmiYMFJeseyW5UEL8F-Rq6GSnZAGbM2hTzDnRqA_lL0wnzUGv2vVOr9r1qn3tFe1l6eUlfTF7cn9XLp4L8OoCYLY4jQmD9fkPV17nCto16O2ZoyLt6CnpbD0FS84nsrN20f_rjt_UmKJM</recordid><startdate>20081215</startdate><enddate>20081215</enddate><creator>Singh, Okram Mukherjee</creator><creator>Singh, Sarangthem Joychandra</creator><creator>Devi, Mutum Babita</creator><creator>Devi, Laitonjam Nalini</creator><creator>Singh, Nameirakpam Irabanta</creator><creator>Lee, Sang-Gyeong</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081215</creationdate><title>Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones</title><author>Singh, Okram Mukherjee ; Singh, Sarangthem Joychandra ; Devi, Mutum Babita ; Devi, Laitonjam Nalini ; Singh, Nameirakpam Irabanta ; Lee, Sang-Gyeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-48069a7bb3cf9209e5be3c0abc96ed80b7182824bba68ba2aa3a4f87d4c1048c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - pharmacology</topic><topic>Aspergillus niger</topic><topic>Aspergillus niger - metabolism</topic><topic>Biological and medical sciences</topic><topic>Catalysis</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Copper - chemistry</topic><topic>Dihydropyrimidine</topic><topic>Drug Design</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Models, Chemical</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrimidinones - chemical synthesis</topic><topic>Pyrimidinones - pharmacology</topic><topic>Solvent-free</topic><topic>Solvents - chemistry</topic><topic>Time Factors</topic><topic>Trichoderma - metabolism</topic><topic>Trichoderma koningii</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Okram Mukherjee</creatorcontrib><creatorcontrib>Singh, Sarangthem Joychandra</creatorcontrib><creatorcontrib>Devi, Mutum Babita</creatorcontrib><creatorcontrib>Devi, Laitonjam Nalini</creatorcontrib><creatorcontrib>Singh, Nameirakpam Irabanta</creatorcontrib><creatorcontrib>Lee, Sang-Gyeong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Okram Mukherjee</au><au>Singh, Sarangthem Joychandra</au><au>Devi, Mutum Babita</au><au>Devi, Laitonjam Nalini</au><au>Singh, Nameirakpam Irabanta</au><au>Lee, Sang-Gyeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2008-12-15</date><risdate>2008</risdate><volume>18</volume><issue>24</issue><spage>6462</spage><epage>6467</epage><pages>6462-6467</pages><issn>0960-894X</issn><issn>0968-0896</issn><eissn>1464-3405</eissn><eissn>1464-3391</eissn><abstract>The synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported.
Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz.,
Trichoderma hammatum,
Trichoderma koningii and
Aspergillus niger.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>18977139</pmid><doi>10.1016/j.bmcl.2008.10.063</doi><tpages>6</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6462-6467 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal activity Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Aspergillus niger Aspergillus niger - metabolism Biological and medical sciences Catalysis Chemistry, Pharmaceutical - methods Copper - chemistry Dihydropyrimidine Drug Design In Vitro Techniques Medical sciences Microbial Sensitivity Tests Models, Chemical Pharmacology. Drug treatments Pyrimidinones - chemical synthesis Pyrimidinones - pharmacology Solvent-free Solvents - chemistry Time Factors Trichoderma - metabolism Trichoderma koningii |
| title | Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones |
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