Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

The synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported. Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.