CSF 5-HIAA correlates with neuroticism in depressed patients

Background: To examine for relationships between neurotransmitters and personality. Method: 27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ). Result: CSF concentrations of the serotonin metabolite 5-hydroxyin...

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Veröffentlicht in:	Journal of affective disorders 1999, Vol.52 (1), p.247-249
1. Verfasser:	Roy, Alec
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Biological and medical sciences Cerebrospinal fluid monamine metabolites Depressed patients Depression Depressive Disorder, Major - complications Depressive Disorder, Major - diagnosis Depressive Disorder, Major - psychology Female Humans Hydroxyindoleacetic Acid - cerebrospinal fluid Male Medical sciences Mood disorders Neurotic Disorders - cerebrospinal fluid Neurotic Disorders - complications Neurotic Disorders - diagnosis Neuroticism Personality Inventory Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index
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Zusammenfassung:	Background: To examine for relationships between neurotransmitters and personality. Method: 27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ). Result: CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores. Conclusion: Central serotonin may play a role in neuroticism, a personality dimension predisposing to depression. Limitation: The positive correlation may partly reflect collinear relationships between both variables and anxiety/depression.
ISSN:	0165-0327 1573-2517
DOI:	10.1016/S0165-0327(98)00073-1