A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp

A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation....

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-05, Vol.62 (5), p.773-776
Hauptverfasser:	Kim, Dong-Kyoo, Lim, Young Ja, Kim, Jung Sun, Park, Jong Hee, Kim, Nam Deuk, Im, Kwang Sik, Hong, Jongki, Jung, Jee H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cyclitol derivatives DNA Replication - drug effects DNA, Viral - metabolism General pharmacology Glycerol - analogs & derivatives Glycerol - chemistry Glycerol - isolation & purification Glycerol - pharmacology Magnetic Resonance Spectroscopy Marine Medical sciences natural products Nucleic Acid Synthesis Inhibitors - chemical synthesis Nucleic Acid Synthesis Inhibitors - chemistry Nucleic Acid Synthesis Inhibitors - pharmacology Petrosia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Simian virus 40 - metabolism Spectrometry, Mass, Fast Atom Bombardment Sugar Alcohols - chemistry Sugar Alcohols - isolation & purification Sugar Alcohols - pharmacology Topoisomerase I Inhibitors
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Beschreibung
Zusammenfassung:	A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2‘,3‘,4‘,5‘-tetrahydroxycyclopentyl)-3-O-(10‘ ‘-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9804785