Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature
Gastroesophageal reflux, by exposing the pharynx to Helicobacter pylori (H. pylori), is a potential risk factor for laryngo-hypopharyngeal carcinoma. Its possible association has been inconsistent. In this case-control study, we investigated the relationship between H. pylori seropositivity and lary...
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| Veröffentlicht in: | Head & neck 2008-12, Vol.30 (12), p.1624-1627 |
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| container_title | Head & neck |
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| creator | Rezaii, Jalal Tavakoli, Hassan Esfandiari, Khalil Ashegh, Hossein Hasibi, Mehrdad Ghanei, Gholamreza Khosh-Batn, Mahnaz Rashidi, Armin |
| description | Gastroesophageal reflux, by exposing the pharynx to Helicobacter pylori (H. pylori), is a potential risk factor for laryngo-hypopharyngeal carcinoma. Its possible association has been inconsistent. In this case-control study, we investigated the relationship between H. pylori seropositivity and laryngo-hypopharyngeal carcinoma in Iran.
We had 105 healthy controls (group A), 70 cases of laryngeal carcinoma (group B), and 28 cases of hypopharyngeal carcinoma group (group C). Age, sex, smoking habit, alcohol use, and H. pylori serology were determined for all subjects.
Groups were matched in age and alcohol use. Smoking and H. pylori seropositivity were more common in groups B and C, and male sex was more common in group B (compared with group A). In multivariate regression, the effect of smoking (p |
| doi_str_mv | 10.1002/hed.20918 |
| format | Article |
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We had 105 healthy controls (group A), 70 cases of laryngeal carcinoma (group B), and 28 cases of hypopharyngeal carcinoma group (group C). Age, sex, smoking habit, alcohol use, and H. pylori serology were determined for all subjects.
Groups were matched in age and alcohol use. Smoking and H. pylori seropositivity were more common in groups B and C, and male sex was more common in group B (compared with group A). In multivariate regression, the effect of smoking (p <.01, odds ratio [OR] = 2.92) and H. pylori seropositivity (p <.01, OR = 11.49) remained highly significant.
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We had 105 healthy controls (group A), 70 cases of laryngeal carcinoma (group B), and 28 cases of hypopharyngeal carcinoma group (group C). Age, sex, smoking habit, alcohol use, and H. pylori serology were determined for all subjects.
Groups were matched in age and alcohol use. Smoking and H. pylori seropositivity were more common in groups B and C, and male sex was more common in group B (compared with group A). In multivariate regression, the effect of smoking (p <.01, odds ratio [OR] = 2.92) and H. pylori seropositivity (p <.01, OR = 11.49) remained highly significant.
H. pylori is an independent risk factor for laryngo-hypopharyngeal carcinoma.</description><subject>Aged</subject><subject>Carcinoma - blood</subject><subject>Carcinoma - microbiology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Hypopharyngeal Neoplasms - blood</subject><subject>Hypopharyngeal Neoplasms - microbiology</subject><subject>Laryngeal Neoplasms - blood</subject><subject>Laryngeal Neoplasms - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEFOwzAQRS0kREthwQWQV-xSxokTx-yqCihSJTbdR44zIUZOHOyEKkfg1kSlrL6e9GZG8wm5Y7BmAPFjg9U6BsnyC7JkIEUECRcLch3CJwAkGY-vyILlIhNMwJL8bEJw2qjBuI6WOBwRO7pDa7QrlR7Q036yzhtquhr1yVJdRa3yU_fhombqXd-cAJWlWnltOteqJ6pmCBhp1w3eWRqGsZpOox6_DR6pq-nQILVmvqGG0eMNuayVDXh7zhU5vDwftrto__76tt3soz7lEJUxz0sFmuciAYECRFUBomBZrYBXXDBIcxVzWYsEOaSCxSgh5VWcylryPFmRh7-1vXdfI4ahaE3QaK3q0I2hyKSQkDExi_dncSxbrIrem3Z-tPjvLvkFCXdwTA</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Rezaii, Jalal</creator><creator>Tavakoli, Hassan</creator><creator>Esfandiari, Khalil</creator><creator>Ashegh, Hossein</creator><creator>Hasibi, Mehrdad</creator><creator>Ghanei, Gholamreza</creator><creator>Khosh-Batn, Mahnaz</creator><creator>Rashidi, Armin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature</title><author>Rezaii, Jalal ; Tavakoli, Hassan ; Esfandiari, Khalil ; Ashegh, Hossein ; Hasibi, Mehrdad ; Ghanei, Gholamreza ; Khosh-Batn, Mahnaz ; Rashidi, Armin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p540-b248ba0c487307e707dd0ee716fa04d471058a249f73e405712e9054d259f9483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Carcinoma - blood</topic><topic>Carcinoma - microbiology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Hypopharyngeal Neoplasms - blood</topic><topic>Hypopharyngeal Neoplasms - microbiology</topic><topic>Laryngeal Neoplasms - blood</topic><topic>Laryngeal Neoplasms - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezaii, Jalal</creatorcontrib><creatorcontrib>Tavakoli, Hassan</creatorcontrib><creatorcontrib>Esfandiari, Khalil</creatorcontrib><creatorcontrib>Ashegh, Hossein</creatorcontrib><creatorcontrib>Hasibi, Mehrdad</creatorcontrib><creatorcontrib>Ghanei, Gholamreza</creatorcontrib><creatorcontrib>Khosh-Batn, Mahnaz</creatorcontrib><creatorcontrib>Rashidi, Armin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezaii, Jalal</au><au>Tavakoli, Hassan</au><au>Esfandiari, Khalil</au><au>Ashegh, Hossein</au><au>Hasibi, Mehrdad</au><au>Ghanei, Gholamreza</au><au>Khosh-Batn, Mahnaz</au><au>Rashidi, Armin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2008-12</date><risdate>2008</risdate><volume>30</volume><issue>12</issue><spage>1624</spage><epage>1627</epage><pages>1624-1627</pages><eissn>1097-0347</eissn><abstract>Gastroesophageal reflux, by exposing the pharynx to Helicobacter pylori (H. pylori), is a potential risk factor for laryngo-hypopharyngeal carcinoma. Its possible association has been inconsistent. In this case-control study, we investigated the relationship between H. pylori seropositivity and laryngo-hypopharyngeal carcinoma in Iran.
We had 105 healthy controls (group A), 70 cases of laryngeal carcinoma (group B), and 28 cases of hypopharyngeal carcinoma group (group C). Age, sex, smoking habit, alcohol use, and H. pylori serology were determined for all subjects.
Groups were matched in age and alcohol use. Smoking and H. pylori seropositivity were more common in groups B and C, and male sex was more common in group B (compared with group A). In multivariate regression, the effect of smoking (p <.01, odds ratio [OR] = 2.92) and H. pylori seropositivity (p <.01, OR = 11.49) remained highly significant.
H. pylori is an independent risk factor for laryngo-hypopharyngeal carcinoma.</abstract><cop>United States</cop><pmid>18767170</pmid><doi>10.1002/hed.20918</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Carcinoma - blood Carcinoma - microbiology Case-Control Studies Female Gastroesophageal Reflux - complications Helicobacter Infections - complications Helicobacter pylori - isolation & purification Humans Hypopharyngeal Neoplasms - blood Hypopharyngeal Neoplasms - microbiology Laryngeal Neoplasms - blood Laryngeal Neoplasms - microbiology Male Middle Aged Multivariate Analysis Odds Ratio Regression Analysis Risk Factors |
| title | Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature |
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