Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the mod...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-12, Vol.18 (23), p.6050-6053
Hauptverfasser:	SHIONO, Yoshihito, SHIMANUKI, Keiko, HIRAMATSU, Fuminori, KOSEKI, Takuya, TETSUYA, Murayama, FUJISAWA, Nozomi, KIMURA, Ken-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology HL-60 Cells Humans Hypocreales - chemistry Japan Medical sciences Molecular Structure Oryza - microbiology Oryza sativa Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology
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Zusammenfassung:	Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.10.032