UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation
Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step i...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5418), p.1372-1376 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Keppler, Oliver T. Hinderlich, Stephan Langner, Josmar Schwartz-Albiez, Reinhard Reutter, Werner Pawlita, Michael |
| description | Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules. |
| doi_str_mv | 10.1126/science.284.5418.1372 |
| format | Article |
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Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.284.5418.1372</identifier><identifier>PMID: 10334995</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Antigens, CD - metabolism ; Antigens, Differentiation, B-Lymphocyte - metabolism ; B lymphocytes ; Biological and medical sciences ; Carbohydrate Epimerases - genetics ; Carbohydrate Epimerases - metabolism ; Cell Adhesion Molecules - metabolism ; Cell coat. Cell surface ; Cell lines ; Cell Membrane - metabolism ; Cell membranes ; Cell structures and functions ; Cells ; Cells (Biology) ; Complementary DNA ; COS cells ; Culture Media ; Escherichia coli Proteins ; Eukaryotes ; Eukaryotic cells ; Fundamental and applied biological sciences. Psychology ; Glycoconjugates ; Glycoconjugates - metabolism ; Histocompatibility Antigens Class I - biosynthesis ; HL-60 Cells ; Humans ; Lectins - metabolism ; Lewis X Antigen - biosynthesis ; Lipopolysaccharide Receptors - biosynthesis ; Messenger RNA ; Molecular and cellular biology ; Molecules ; Myeloid cells ; Oligosaccharides - biosynthesis ; Physiological regulation ; Plasma membranes ; Rats ; Sialic Acid Binding Ig-like Lectin 2 ; Sialic acids ; Sialic Acids - biosynthesis ; Transcription, Genetic ; Transfection ; Tumor Cells, Cultured</subject><ispartof>Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5418), p.1372-1376</ispartof><rights>Copyright 1999 American Association for the Advancement of Science</rights><rights>1999 INIST-CNRS</rights><rights>COPYRIGHT 1999 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1999 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c696t-b51daa39d36f9b3860c68bce082eae85d93b5cd1625e5358fbb02e190ae30ec73</citedby><cites>FETCH-LOGICAL-c696t-b51daa39d36f9b3860c68bce082eae85d93b5cd1625e5358fbb02e190ae30ec73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2899100$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2899100$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1802384$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10334995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keppler, Oliver T.</creatorcontrib><creatorcontrib>Hinderlich, Stephan</creatorcontrib><creatorcontrib>Langner, Josmar</creatorcontrib><creatorcontrib>Schwartz-Albiez, Reinhard</creatorcontrib><creatorcontrib>Reutter, Werner</creatorcontrib><creatorcontrib>Pawlita, Michael</creatorcontrib><title>UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.</description><subject>Animals</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, B-Lymphocyte - metabolism</subject><subject>B lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Epimerases - genetics</subject><subject>Carbohydrate Epimerases - metabolism</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell coat. Cell surface</subject><subject>Cell lines</subject><subject>Cell Membrane - metabolism</subject><subject>Cell membranes</subject><subject>Cell structures and functions</subject><subject>Cells</subject><subject>Cells (Biology)</subject><subject>Complementary DNA</subject><subject>COS cells</subject><subject>Culture Media</subject><subject>Escherichia coli Proteins</subject><subject>Eukaryotes</subject><subject>Eukaryotic cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoconjugates</subject><subject>Glycoconjugates - metabolism</subject><subject>Histocompatibility Antigens Class I - biosynthesis</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Lectins - metabolism</subject><subject>Lewis X Antigen - biosynthesis</subject><subject>Lipopolysaccharide Receptors - biosynthesis</subject><subject>Messenger RNA</subject><subject>Molecular and cellular biology</subject><subject>Molecules</subject><subject>Myeloid cells</subject><subject>Oligosaccharides - biosynthesis</subject><subject>Physiological regulation</subject><subject>Plasma membranes</subject><subject>Rats</subject><subject>Sialic Acid Binding Ig-like Lectin 2</subject><subject>Sialic acids</subject><subject>Sialic Acids - biosynthesis</subject><subject>Transcription, Genetic</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s-L1DAUB_Agijuu_gcqPYh42I750bSJFxnHdVwYdsRxvYY0fS1Z0nZMWnD_ezN0UAfmMOQQyPskvPC-CL0ieE4Izd8HY6EzMKcim_OMiDlhBX2EZgRLnkqK2WM0w5jlqcAFv0DPQrjHONYke4ouCGYsk5LP0Me7z9_SlTO3C5PQ9HpnW_A6wIdkkXyHZnR66H3S18kSnEu2o6-1gWRrtXuIJdt3z9GTWrsALw77Jbr7cv1j-TVdb1Y3y8U6NbnMh7TkpNKayYrltSyZyLHJRWkACwoaBK8kK7mpSE45cMZFXZaYApFYA8NgCnaJ3k7v7nz_a4QwqNYGE5vSHfRjULksioxkNMKrCTbagbJd3Q9emwa6-C_Xd1DbeLzgWSFzKmTk6QkeVwWtNaf8uyMfyQC_h0aPIaib7e3ZdPPzbPppdS4Vq_URvTpFTe8cNKDifJabI84nbnwfgoda7bxttX9QBKt95tQhcypmTu0zp_aZi_deH0Yzli1U_92aQhbBmwPQwWhXe90ZG_45gSkTWWQvJ3YfYuj-lmNrksQk_wFaXuPy</recordid><startdate>19990521</startdate><enddate>19990521</enddate><creator>Keppler, Oliver T.</creator><creator>Hinderlich, Stephan</creator><creator>Langner, Josmar</creator><creator>Schwartz-Albiez, Reinhard</creator><creator>Reutter, Werner</creator><creator>Pawlita, Michael</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7X8</scope></search><sort><creationdate>19990521</creationdate><title>UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation</title><author>Keppler, Oliver T. ; Hinderlich, Stephan ; Langner, Josmar ; Schwartz-Albiez, Reinhard ; Reutter, Werner ; Pawlita, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c696t-b51daa39d36f9b3860c68bce082eae85d93b5cd1625e5358fbb02e190ae30ec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, B-Lymphocyte - metabolism</topic><topic>B lymphocytes</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Epimerases - genetics</topic><topic>Carbohydrate Epimerases - metabolism</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell coat. Cell surface</topic><topic>Cell lines</topic><topic>Cell Membrane - metabolism</topic><topic>Cell membranes</topic><topic>Cell structures and functions</topic><topic>Cells</topic><topic>Cells (Biology)</topic><topic>Complementary DNA</topic><topic>COS cells</topic><topic>Culture Media</topic><topic>Escherichia coli Proteins</topic><topic>Eukaryotes</topic><topic>Eukaryotic cells</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoconjugates</topic><topic>Glycoconjugates - metabolism</topic><topic>Histocompatibility Antigens Class I - biosynthesis</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Lectins - metabolism</topic><topic>Lewis X Antigen - biosynthesis</topic><topic>Lipopolysaccharide Receptors - biosynthesis</topic><topic>Messenger RNA</topic><topic>Molecular and cellular biology</topic><topic>Molecules</topic><topic>Myeloid cells</topic><topic>Oligosaccharides - biosynthesis</topic><topic>Physiological regulation</topic><topic>Plasma membranes</topic><topic>Rats</topic><topic>Sialic Acid Binding Ig-like Lectin 2</topic><topic>Sialic acids</topic><topic>Sialic Acids - biosynthesis</topic><topic>Transcription, Genetic</topic><topic>Transfection</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keppler, Oliver T.</creatorcontrib><creatorcontrib>Hinderlich, Stephan</creatorcontrib><creatorcontrib>Langner, Josmar</creatorcontrib><creatorcontrib>Schwartz-Albiez, Reinhard</creatorcontrib><creatorcontrib>Reutter, Werner</creatorcontrib><creatorcontrib>Pawlita, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keppler, Oliver T.</au><au>Hinderlich, Stephan</au><au>Langner, Josmar</au><au>Schwartz-Albiez, Reinhard</au><au>Reutter, Werner</au><au>Pawlita, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1999-05-21</date><risdate>1999</risdate><volume>284</volume><issue>5418</issue><spage>1372</spage><epage>1376</epage><pages>1372-1376</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>10334995</pmid><doi>10.1126/science.284.5418.1372</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5418), p.1372-1376 |
| issn | 0036-8075 1095-9203 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Antigens, CD - metabolism Antigens, Differentiation, B-Lymphocyte - metabolism B lymphocytes Biological and medical sciences Carbohydrate Epimerases - genetics Carbohydrate Epimerases - metabolism Cell Adhesion Molecules - metabolism Cell coat. Cell surface Cell lines Cell Membrane - metabolism Cell membranes Cell structures and functions Cells Cells (Biology) Complementary DNA COS cells Culture Media Escherichia coli Proteins Eukaryotes Eukaryotic cells Fundamental and applied biological sciences. Psychology Glycoconjugates Glycoconjugates - metabolism Histocompatibility Antigens Class I - biosynthesis HL-60 Cells Humans Lectins - metabolism Lewis X Antigen - biosynthesis Lipopolysaccharide Receptors - biosynthesis Messenger RNA Molecular and cellular biology Molecules Myeloid cells Oligosaccharides - biosynthesis Physiological regulation Plasma membranes Rats Sialic Acid Binding Ig-like Lectin 2 Sialic acids Sialic Acids - biosynthesis Transcription, Genetic Transfection Tumor Cells, Cultured |
| title | UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation |
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