UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5418), p.1372-1376
Hauptverfasser:	Keppler, Oliver T., Hinderlich, Stephan, Langner, Josmar, Schwartz-Albiez, Reinhard, Reutter, Werner, Pawlita, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Antigens, Differentiation, B-Lymphocyte - metabolism B lymphocytes Biological and medical sciences Carbohydrate Epimerases - genetics Carbohydrate Epimerases - metabolism Cell Adhesion Molecules - metabolism Cell coat. Cell surface Cell lines Cell Membrane - metabolism Cell membranes Cell structures and functions Cells Cells (Biology) Complementary DNA COS cells Culture Media Escherichia coli Proteins Eukaryotes Eukaryotic cells Fundamental and applied biological sciences. Psychology Glycoconjugates Glycoconjugates - metabolism Histocompatibility Antigens Class I - biosynthesis HL-60 Cells Humans Lectins - metabolism Lewis X Antigen - biosynthesis Lipopolysaccharide Receptors - biosynthesis Messenger RNA Molecular and cellular biology Molecules Myeloid cells Oligosaccharides - biosynthesis Physiological regulation Plasma membranes Rats Sialic Acid Binding Ig-like Lectin 2 Sialic acids Sialic Acids - biosynthesis Transcription, Genetic Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.284.5418.1372