The correlation of thrombolysis in myocardial infarction frame count with insulin resistance in patients with slow coronary flow
BACKGROUNDIt has been reported that coronary endothelial dysfunction plays an important pathogenetic role in patients with slow coronary flow (SCF). Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while endothelial dysfunction is defined as paradoxi...
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| Veröffentlicht in: | Coronary artery disease 2008-12, Vol.19 (8), p.591-595 |
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| creator | Ozcan, Turkay Gen, Ramazan Akbay, Esen Horoz, Mehmet Akcay, Burak Genctoy, Gultekin Muslu, Necati Camsari, Ahmet Cicek, Dilek Gok, Ebru Kiykim, Ahmet |
| description | BACKGROUNDIt has been reported that coronary endothelial dysfunction plays an important pathogenetic role in patients with slow coronary flow (SCF). Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while endothelial dysfunction is defined as paradoxical or inadequate endothelial-mediated vasodilation. In this study, we aimed to evaluate insulin resistance in patients with SCF.
METHODSThe study population included 25 patients with SCF and 28 healthy controls. Insulin resistance was estimated via homeostasis model assessment insulin resistance index (HOMA-IR).
RESULTSPatients with SCF had higher high-sensitive C-reactive protein (hs-CRP) and HOMA-IR scores (P |
| doi_str_mv | 10.1097/MCA.0b013e32831381c8 |
| format | Article |
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METHODSThe study population included 25 patients with SCF and 28 healthy controls. Insulin resistance was estimated via homeostasis model assessment insulin resistance index (HOMA-IR).
RESULTSPatients with SCF had higher high-sensitive C-reactive protein (hs-CRP) and HOMA-IR scores (P<0.05) than controls. Mean thrombolysis in myocardial infarction frame count had significant correlation with hs-CRP, fasting plasma insulin levels and HOMA-IR score (r=0.566, P<0.05; r=0.883, P<0.05; r=0.884, P<0.05, respectively).
CONCLUSIONIn patients with SCF, thrombolysis in myocardial infarction frame counts and hs-CRP are correlated with increased insulin resistance and thus, it can be suggested that insulin resistance and inflammation may, in part, have a role in the pathogenesis of SCF.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/MCA.0b013e32831381c8</identifier><identifier>PMID: 19005294</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Biomarkers - blood ; Blood Flow Velocity ; C-Reactive Protein - metabolism ; Case-Control Studies ; Cineangiography ; Contrast Media ; Coronary Angiography ; Coronary Circulation ; Coronary Disease - blood ; Coronary Disease - diagnostic imaging ; Coronary Disease - physiopathology ; Coronary Vessels - pathology ; Coronary Vessels - physiopathology ; Female ; Humans ; Inflammation Mediators - blood ; Insulin - blood ; Insulin Resistance ; Iohexol - analogs & derivatives ; Male ; Middle Aged ; Models, Biological ; Myocardial Infarction - blood ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - physiopathology ; Thrombolytic Therapy ; Up-Regulation</subject><ispartof>Coronary artery disease, 2008-12, Vol.19 (8), p.591-595</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3507-321fc12eb5e4ed9bfe42dba9aa5521d631a4f57abd44c47c9c8555bb7c5f92f13</citedby><cites>FETCH-LOGICAL-c3507-321fc12eb5e4ed9bfe42dba9aa5521d631a4f57abd44c47c9c8555bb7c5f92f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19005294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozcan, Turkay</creatorcontrib><creatorcontrib>Gen, Ramazan</creatorcontrib><creatorcontrib>Akbay, Esen</creatorcontrib><creatorcontrib>Horoz, Mehmet</creatorcontrib><creatorcontrib>Akcay, Burak</creatorcontrib><creatorcontrib>Genctoy, Gultekin</creatorcontrib><creatorcontrib>Muslu, Necati</creatorcontrib><creatorcontrib>Camsari, Ahmet</creatorcontrib><creatorcontrib>Cicek, Dilek</creatorcontrib><creatorcontrib>Gok, Ebru</creatorcontrib><creatorcontrib>Kiykim, Ahmet</creatorcontrib><title>The correlation of thrombolysis in myocardial infarction frame count with insulin resistance in patients with slow coronary flow</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>BACKGROUNDIt has been reported that coronary endothelial dysfunction plays an important pathogenetic role in patients with slow coronary flow (SCF). Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while endothelial dysfunction is defined as paradoxical or inadequate endothelial-mediated vasodilation. In this study, we aimed to evaluate insulin resistance in patients with SCF.
METHODSThe study population included 25 patients with SCF and 28 healthy controls. Insulin resistance was estimated via homeostasis model assessment insulin resistance index (HOMA-IR).
RESULTSPatients with SCF had higher high-sensitive C-reactive protein (hs-CRP) and HOMA-IR scores (P<0.05) than controls. Mean thrombolysis in myocardial infarction frame count had significant correlation with hs-CRP, fasting plasma insulin levels and HOMA-IR score (r=0.566, P<0.05; r=0.883, P<0.05; r=0.884, P<0.05, respectively).
CONCLUSIONIn patients with SCF, thrombolysis in myocardial infarction frame counts and hs-CRP are correlated with increased insulin resistance and thus, it can be suggested that insulin resistance and inflammation may, in part, have a role in the pathogenesis of SCF.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood Flow Velocity</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Cineangiography</subject><subject>Contrast Media</subject><subject>Coronary Angiography</subject><subject>Coronary Circulation</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary Vessels - pathology</subject><subject>Coronary Vessels - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Iohexol - analogs & derivatives</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Thrombolytic Therapy</subject><subject>Up-Regulation</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9v1DAQxS0EokvhGyCUE7eU8b91fKxWQCsV9VLOluOMlYATL7aj1d760fGyK1XiYFuj-b03o2dCPlK4oaDVlx-72xvogXLkrOOUd9R1r8iGCsVb2XF4TTagpWi3mnVX5F3OvwCokEq-JVdUA0imxYY8P43YuJgSBlumuDTRN2VMce5jOOYpN9PSzMfobBomG2rlbXL_QJ_sfJKuS2kOUxlrL6-h4gmrrtjF4Um8r7a4lHxmcoiH07i42HRsfK3ekzfehowfLu81-fnt69Purn14_H6_u31oHZegWs6od5RhL1HgoHuPgg291dZKyeiw5dQKL5XtByGcUE67TkrZ98pJr5mn_Jp8PvvuU_yzYi5mnrLDEOyCcc1mq5XiXLIKijPoUsw5oTf7NM11XUPBnJI3NXnzf_JV9univ_YzDi-iS9QvvocYCqb8O6wHTGZEG8pooH6OlkBbBtDRekFbDyj-F0Lnk1w</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Ozcan, Turkay</creator><creator>Gen, Ramazan</creator><creator>Akbay, Esen</creator><creator>Horoz, Mehmet</creator><creator>Akcay, Burak</creator><creator>Genctoy, Gultekin</creator><creator>Muslu, Necati</creator><creator>Camsari, Ahmet</creator><creator>Cicek, Dilek</creator><creator>Gok, Ebru</creator><creator>Kiykim, Ahmet</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>The correlation of thrombolysis in myocardial infarction frame count with insulin resistance in patients with slow coronary flow</title><author>Ozcan, Turkay ; Gen, Ramazan ; Akbay, Esen ; Horoz, Mehmet ; Akcay, Burak ; Genctoy, Gultekin ; Muslu, Necati ; Camsari, Ahmet ; Cicek, Dilek ; Gok, Ebru ; Kiykim, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3507-321fc12eb5e4ed9bfe42dba9aa5521d631a4f57abd44c47c9c8555bb7c5f92f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood Flow Velocity</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Cineangiography</topic><topic>Contrast Media</topic><topic>Coronary Angiography</topic><topic>Coronary Circulation</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary Vessels - pathology</topic><topic>Coronary Vessels - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Iohexol - analogs & derivatives</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Thrombolytic Therapy</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozcan, Turkay</creatorcontrib><creatorcontrib>Gen, Ramazan</creatorcontrib><creatorcontrib>Akbay, Esen</creatorcontrib><creatorcontrib>Horoz, Mehmet</creatorcontrib><creatorcontrib>Akcay, Burak</creatorcontrib><creatorcontrib>Genctoy, Gultekin</creatorcontrib><creatorcontrib>Muslu, Necati</creatorcontrib><creatorcontrib>Camsari, Ahmet</creatorcontrib><creatorcontrib>Cicek, Dilek</creatorcontrib><creatorcontrib>Gok, Ebru</creatorcontrib><creatorcontrib>Kiykim, Ahmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozcan, Turkay</au><au>Gen, Ramazan</au><au>Akbay, Esen</au><au>Horoz, Mehmet</au><au>Akcay, Burak</au><au>Genctoy, Gultekin</au><au>Muslu, Necati</au><au>Camsari, Ahmet</au><au>Cicek, Dilek</au><au>Gok, Ebru</au><au>Kiykim, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The correlation of thrombolysis in myocardial infarction frame count with insulin resistance in patients with slow coronary flow</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2008-12</date><risdate>2008</risdate><volume>19</volume><issue>8</issue><spage>591</spage><epage>595</epage><pages>591-595</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>BACKGROUNDIt has been reported that coronary endothelial dysfunction plays an important pathogenetic role in patients with slow coronary flow (SCF). Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while endothelial dysfunction is defined as paradoxical or inadequate endothelial-mediated vasodilation. In this study, we aimed to evaluate insulin resistance in patients with SCF.
METHODSThe study population included 25 patients with SCF and 28 healthy controls. Insulin resistance was estimated via homeostasis model assessment insulin resistance index (HOMA-IR).
RESULTSPatients with SCF had higher high-sensitive C-reactive protein (hs-CRP) and HOMA-IR scores (P<0.05) than controls. Mean thrombolysis in myocardial infarction frame count had significant correlation with hs-CRP, fasting plasma insulin levels and HOMA-IR score (r=0.566, P<0.05; r=0.883, P<0.05; r=0.884, P<0.05, respectively).
CONCLUSIONIn patients with SCF, thrombolysis in myocardial infarction frame counts and hs-CRP are correlated with increased insulin resistance and thus, it can be suggested that insulin resistance and inflammation may, in part, have a role in the pathogenesis of SCF.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19005294</pmid><doi>10.1097/MCA.0b013e32831381c8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Coronary artery disease, 2008-12, Vol.19 (8), p.591-595 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Biomarkers - blood Blood Flow Velocity C-Reactive Protein - metabolism Case-Control Studies Cineangiography Contrast Media Coronary Angiography Coronary Circulation Coronary Disease - blood Coronary Disease - diagnostic imaging Coronary Disease - physiopathology Coronary Vessels - pathology Coronary Vessels - physiopathology Female Humans Inflammation Mediators - blood Insulin - blood Insulin Resistance Iohexol - analogs & derivatives Male Middle Aged Models, Biological Myocardial Infarction - blood Myocardial Infarction - diagnostic imaging Myocardial Infarction - physiopathology Thrombolytic Therapy Up-Regulation |
| title | The correlation of thrombolysis in myocardial infarction frame count with insulin resistance in patients with slow coronary flow |
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