Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

Abstract Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.

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Bibliographische Detailangaben
Veröffentlicht in:	Radiotherapy and oncology 2008-11, Vol.89 (2), p.222-226
Hauptverfasser:	Lara, Pedro Carlos, Lloret, Marta, Clavo, Bernardino, Apolinario, Rosa Maria, Bordón, Elisa, Rey, Agustin, Falcón, Orlando, Alonso, Ana Ruiz, Belka, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over angiogenesis Antigens, Nuclear - genetics Cervical cancer DNA-Binding Proteins - genetics Down-Regulation Female Hematology, Oncology and Palliative Medicine Humans Hypoxia Hypoxia - genetics Immunoenzyme Techniques Ku Autoantigen Ku70/80 Middle Aged NHEJ repair p53 Prospective Studies Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - radiotherapy
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Beschreibung
Zusammenfassung:	Abstract Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2008.07.018