The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli
E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide rece...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 1999/04/15, Vol.22(4), pp.432-434 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 434 |
|---|---|
| container_issue | 4 |
| container_start_page | 432 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 22 |
| creator | ASAI, Yasuyuki NOZU, Yukio IKEUCHI, Takayuki NARAZAKI, Ryuichi IWAMOTO, Kiyoshi WATANABE, Sumio |
| description | E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide receptor. The pyrogenic activity of E5531 is weak and the pyrogenic profile of E5531 is different from that of USP (United States Pharmacopoeia) reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX. |
| doi_str_mv | 10.1248/bpb.22.432 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69771363</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17299149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-5a40e0dd6036f486ae40df6cdab000e81dd3e0b6e1e7f14ff91ba437f1d4725c3</originalsourceid><addsrcrecordid>eNqF0UtvEzEQAGALgWhauPADkCUQB8QGv3d9jKItVIrEpZw4rLz2uHG0WQd7t6L_HqeJCuLCxQ_Npxl7BqE3lCwpE83n_tAvGVsKzp6hBeWiriSj8jlaEE2bSlHZXKDLnHeEkJow_hJdUMJZI5VeoB-3W8Ct92AnHD2eym0TDsHhFV6NZoh3n3ArJac4jvga7iHhm9HNFhzuH3A7ujjFX2HEPsU9brPdQgp2Gwy2cQiv0Atvhgyvz_sV-n7d3q6_VptvX27Wq01lldRTJY0gQJxThCsvGmVAEOeVdaYvL4aGOseB9Aoo1J4K7zXtjeDl7ETNpOVX6MMp7yHFnzPkqduHbGEYzAhxzp3SdU254v-FtGZaU6ELfPcP3MU5lX4UI0TpKhWyKerjSdkUc07gu0MKe5MeOkq642S6MpmOsa5MpuC355Rzvwf3Fz2NooD3Z2CyNYNPZrQh_3ENkbw-_mF9Yrs8mTt4ips0BTvAsSTVmj-WPS2l-lPUbk3qYOS_AUi2qo4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449181458</pqid></control><display><type>article</type><title>The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>ASAI, Yasuyuki ; NOZU, Yukio ; IKEUCHI, Takayuki ; NARAZAKI, Ryuichi ; IWAMOTO, Kiyoshi ; WATANABE, Sumio</creator><creatorcontrib>ASAI, Yasuyuki ; NOZU, Yukio ; IKEUCHI, Takayuki ; NARAZAKI, Ryuichi ; IWAMOTO, Kiyoshi ; WATANABE, Sumio</creatorcontrib><description>E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide receptor. The pyrogenic activity of E5531 is weak and the pyrogenic profile of E5531 is different from that of USP (United States Pharmacopoeia) reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.22.432</identifier><identifier>PMID: 10328569</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Analgesics, Non-Narcotic - therapeutic use ; Animals ; Biological and medical sciences ; Dose-Response Relationship, Drug ; endotoxin ; Endotoxins - pharmacology ; Escherichia coli ; fever ; Fever - chemically induced ; Fever - drug therapy ; General and cellular metabolism. Vitamins ; limulus amebocyte lysate ; lipid A ; Lipid A - analogs & derivatives ; Lipid A - therapeutic use ; Medical sciences ; Pharmacology. Drug treatments ; pyrogenicity ; Rabbits</subject><ispartof>Biological and Pharmaceutical Bulletin, 1999/04/15, Vol.22(4), pp.432-434</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-5a40e0dd6036f486ae40df6cdab000e81dd3e0b6e1e7f14ff91ba437f1d4725c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1805373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10328569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ASAI, Yasuyuki</creatorcontrib><creatorcontrib>NOZU, Yukio</creatorcontrib><creatorcontrib>IKEUCHI, Takayuki</creatorcontrib><creatorcontrib>NARAZAKI, Ryuichi</creatorcontrib><creatorcontrib>IWAMOTO, Kiyoshi</creatorcontrib><creatorcontrib>WATANABE, Sumio</creatorcontrib><title>The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide receptor. The pyrogenic activity of E5531 is weak and the pyrogenic profile of E5531 is different from that of USP (United States Pharmacopoeia) reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX.</description><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>endotoxin</subject><subject>Endotoxins - pharmacology</subject><subject>Escherichia coli</subject><subject>fever</subject><subject>Fever - chemically induced</subject><subject>Fever - drug therapy</subject><subject>General and cellular metabolism. Vitamins</subject><subject>limulus amebocyte lysate</subject><subject>lipid A</subject><subject>Lipid A - analogs & derivatives</subject><subject>Lipid A - therapeutic use</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>pyrogenicity</subject><subject>Rabbits</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtvEzEQAGALgWhauPADkCUQB8QGv3d9jKItVIrEpZw4rLz2uHG0WQd7t6L_HqeJCuLCxQ_Npxl7BqE3lCwpE83n_tAvGVsKzp6hBeWiriSj8jlaEE2bSlHZXKDLnHeEkJow_hJdUMJZI5VeoB-3W8Ct92AnHD2eym0TDsHhFV6NZoh3n3ArJac4jvga7iHhm9HNFhzuH3A7ujjFX2HEPsU9brPdQgp2Gwy2cQiv0Atvhgyvz_sV-n7d3q6_VptvX27Wq01lldRTJY0gQJxThCsvGmVAEOeVdaYvL4aGOseB9Aoo1J4K7zXtjeDl7ETNpOVX6MMp7yHFnzPkqduHbGEYzAhxzp3SdU254v-FtGZaU6ELfPcP3MU5lX4UI0TpKhWyKerjSdkUc07gu0MKe5MeOkq642S6MpmOsa5MpuC355Rzvwf3Fz2NooD3Z2CyNYNPZrQh_3ENkbw-_mF9Yrs8mTt4ips0BTvAsSTVmj-WPS2l-lPUbk3qYOS_AUi2qo4</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>ASAI, Yasuyuki</creator><creator>NOZU, Yukio</creator><creator>IKEUCHI, Takayuki</creator><creator>NARAZAKI, Ryuichi</creator><creator>IWAMOTO, Kiyoshi</creator><creator>WATANABE, Sumio</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7QL</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli</title><author>ASAI, Yasuyuki ; NOZU, Yukio ; IKEUCHI, Takayuki ; NARAZAKI, Ryuichi ; IWAMOTO, Kiyoshi ; WATANABE, Sumio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-5a40e0dd6036f486ae40df6cdab000e81dd3e0b6e1e7f14ff91ba437f1d4725c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>endotoxin</topic><topic>Endotoxins - pharmacology</topic><topic>Escherichia coli</topic><topic>fever</topic><topic>Fever - chemically induced</topic><topic>Fever - drug therapy</topic><topic>General and cellular metabolism. Vitamins</topic><topic>limulus amebocyte lysate</topic><topic>lipid A</topic><topic>Lipid A - analogs & derivatives</topic><topic>Lipid A - therapeutic use</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>pyrogenicity</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ASAI, Yasuyuki</creatorcontrib><creatorcontrib>NOZU, Yukio</creatorcontrib><creatorcontrib>IKEUCHI, Takayuki</creatorcontrib><creatorcontrib>NARAZAKI, Ryuichi</creatorcontrib><creatorcontrib>IWAMOTO, Kiyoshi</creatorcontrib><creatorcontrib>WATANABE, Sumio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ASAI, Yasuyuki</au><au>NOZU, Yukio</au><au>IKEUCHI, Takayuki</au><au>NARAZAKI, Ryuichi</au><au>IWAMOTO, Kiyoshi</au><au>WATANABE, Sumio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>22</volume><issue>4</issue><spage>432</spage><epage>434</epage><pages>432-434</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide receptor. The pyrogenic activity of E5531 is weak and the pyrogenic profile of E5531 is different from that of USP (United States Pharmacopoeia) reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>10328569</pmid><doi>10.1248/bpb.22.432</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1999/04/15, Vol.22(4), pp.432-434 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69771363 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Analgesics, Non-Narcotic - therapeutic use Animals Biological and medical sciences Dose-Response Relationship, Drug endotoxin Endotoxins - pharmacology Escherichia coli fever Fever - chemically induced Fever - drug therapy General and cellular metabolism. Vitamins limulus amebocyte lysate lipid A Lipid A - analogs & derivatives Lipid A - therapeutic use Medical sciences Pharmacology. Drug treatments pyrogenicity Rabbits |
| title | The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A23%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20the%20Lipid%20A%20Analog,%20E5531%20on%20Fever%20Induced%20by%20Endotoxin%20from%20Escherichia%20coli&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=ASAI,%20Yasuyuki&rft.date=1999-04-01&rft.volume=22&rft.issue=4&rft.spage=432&rft.epage=434&rft.pages=432-434&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.22.432&rft_dat=%3Cproquest_cross%3E17299149%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449181458&rft_id=info:pmid/10328569&rfr_iscdi=true |