The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli

E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide rece...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 1999/04/15, Vol.22(4), pp.432-434
Hauptverfasser:	ASAI, Yasuyuki, NOZU, Yukio, IKEUCHI, Takayuki, NARAZAKI, Ryuichi, IWAMOTO, Kiyoshi, WATANABE, Sumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Non-Narcotic - therapeutic use Animals Biological and medical sciences Dose-Response Relationship, Drug endotoxin Endotoxins - pharmacology Escherichia coli fever Fever - chemically induced Fever - drug therapy General and cellular metabolism. Vitamins limulus amebocyte lysate lipid A Lipid A - analogs & derivatives Lipid A - therapeutic use Medical sciences Pharmacology. Drug treatments pyrogenicity Rabbits
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide receptor. The pyrogenic activity of E5531 is weak and the pyrogenic profile of E5531 is different from that of USP (United States Pharmacopoeia) reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.22.432