Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence; (Ru-R8) is passively, efficiently and very rapidly transported...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2008-01 (42), p.5307-5309
Hauptverfasser:	Neugebauer, Ute, Pellegrin, Yann, Devocelle, Marc, Forster, Robert J, Signac, William, Moran, Niamh, Keyes, Tia E
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - cytology Cell Membrane - metabolism Cell Membrane Permeability Cytoplasm - metabolism Fluorescent Dyes - chemistry Humans Luminescent Measurements Molecular Structure Multiple Myeloma - diagnosis Multiple Myeloma - pathology Oligopeptides - chemistry Organometallic Compounds - chemistry Organometallic Compounds - metabolism Oxygen - chemistry Pyridines - chemistry Ruthenium - chemistry Structure-Activity Relationship Tissue Distribution
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Beschreibung
Zusammenfassung:	Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence; (Ru-R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for its permeablisation.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b810403d