Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants. A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and disc...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-04, Vol.9 (8), p.1185-1188
Hauptverfasser:	Beck, James P., Curry, Matt A., Chorvat, Robert J., Fitzgerald, Larry W., Gilligan, Paul J., Zaczek, Robert, Trainor, George L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Cell Line Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrimidines - chemical synthesis Pyrimidines - pharmacokinetics Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Structure-Activity Relationship Thiones - chemical synthesis Thiones - pharmacokinetics
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Zusammenfassung:	A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants. A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the human CRH-R1 receptor.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00159-6