Transplantation of Anergic Histoincompatible Bone Marrow Allografts

Successful transplantation of organs requires the use of agents capable of suppressing the immune response against alloantigens. 1 – 3 Use of these nonspecific immunosuppressive drugs, however, can lead to the development of opportunistic infection or secondary cancer. 4 – 13 For this reason, a way of specifically suppressing alloreactive T cells without inhibiting the entire T-cell repertoire is an important goal of transplantation immunology. One approach depends on the fact that the immune activation of T cells requires two signals from antigen-presenting cells. 14 – 16 One of these signals is delivered to the T-cell receptor by an immunogenic peptide displayed in the context of . . .