Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families

Members of the RNA-helicase family are defined by several evolutionary conserved motifs. They are found in all organisms – from bacteria to humans – and many viruses. The minimum number of RNA helicases present within a eukaryotic cell can be predicted from the complete sequence of the Saccharomyces...

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Veröffentlicht in:	Trends in Biochemical Sciences 1999-05, Vol.24 (5), p.192-198
Hauptverfasser:	de la Cruz, Jesús, Kressler, Dieter, Linder, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	DEAD box proteins Fungal Proteins - genetics Fungal Proteins - metabolism Mitochondria - enzymology Protein Biosynthesis Ribosomes - metabolism RNA helicases RNA Helicases - chemistry RNA Helicases - metabolism RNA metabolism RNA processing RNA Processing, Post-Transcriptional RNA Splicing RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Translation
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Beschreibung
Zusammenfassung:	Members of the RNA-helicase family are defined by several evolutionary conserved motifs. They are found in all organisms – from bacteria to humans – and many viruses. The minimum number of RNA helicases present within a eukaryotic cell can be predicted from the complete sequence of the Saccharomyces cerevisiae genome. Recent progress in the functional analysis of various family members has given new insights into, and confirmed the significance of these proteins for, most cellular RNA metabolic processes.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(99)01376-6