Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas

Aims: To evaluate the prognostic impact of expression of receptor tyrosine kinases epidermal growth factor receptor (EGFR), HER2, and C‐KIT in relation to established clinicopathological parameters in salivary gland carcinomas. Methods and results: Immunohistochemistry for EGFR, HER2, C‐KIT and th...

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Veröffentlicht in:	Histopathology 2008-11, Vol.53 (5), p.567-577
Hauptverfasser:	Ettl, T, Schwarz, S, Kleinsasser, N, Hartmann, A, Reichert, T E, Driemel, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences C-KIT Carcinoma - diagnosis Carcinoma - mortality Carcinoma - pathology EGFR Female Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Ki-67 Antigen - metabolism Ki67 Male Medical sciences Middle Aged Multivariate Analysis Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis prognostic factors Proto-Oncogene Proteins c-kit - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism salivary gland cancer Salivary Gland Neoplasms - diagnosis Salivary Gland Neoplasms - mortality Salivary Gland Neoplasms - pathology Survival Analysis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Zusammenfassung:	Aims: To evaluate the prognostic impact of expression of receptor tyrosine kinases epidermal growth factor receptor (EGFR), HER2, and C‐KIT in relation to established clinicopathological parameters in salivary gland carcinomas. Methods and results: Immunohistochemistry for EGFR, HER2, C‐KIT and the proliferation marker Ki67 was performed in 101 cases of salivary gland carcinoma and related to long‐term clinical follow‐up. Immunopositivity of C‐KIT was common in adenoid cystic carcinoma (92%). Lack of C‐KIT expression occurred in salivary duct carcinoma (P
ISSN:	0309-0167 1365-2559
DOI:	10.1111/j.1365-2559.2008.03159.x