Different Allelic Distribution of a Single SNP Between Sexes in Humans

Different Allelic Distribution of a Single SNP Between Sexes in Humans

We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the...

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Veröffentlicht in:Biochemical genetics 2008-12, Vol.46 (11-12), p.733-736
Hauptverfasser: Tripputi, P, Cigognini, D, Bianchi, S, Fedele, L
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biochemistry
Biomedical and Life Sciences
Biomedicine
Female
Gene Frequency
Genotype
Heterozygote
Homozygote
Human Genetics
Humans
Linkage Disequilibrium
Male
Medical Microbiology
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Antigen, T-Cell, alpha-beta - genetics
Zoology
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Beschreibung
Zusammenfassung:We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ² = 8.799, P = 0.012).
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-008-9188-0