Genetics of sleep

Genetics of sleep

Molecular and genetic approaches in several species have provided new insights into the mechanisms of rest-activity and sleep-wake regulation. Many of these discoveries are believed to support hypotheses about sleep functions, which nevertheless remain elusive. In this review we discuss the specific...

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Veröffentlicht in:Annual review of genetics 2008-01, Vol.42 (1), p.361-388
Hauptverfasser: Andretic, Rozi, Franken, Paul, Tafti, Mehdi
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - physiology
Circadian Rhythm
Electroencephalography
Genetics
Homeostasis
Humans
Invertebrates
Invertebrates - genetics
Invertebrates - physiology
Mammals
Mammals - genetics
Mammals - physiology
Models, Genetic
Molecular biology
Neurotransmitter Agents - physiology
Phenotype
Sleep
Sleep - genetics
Sleep - physiology
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Beschreibung
Zusammenfassung:Molecular and genetic approaches in several species have provided new insights into the mechanisms of rest-activity and sleep-wake regulation. Many of these discoveries are believed to support hypotheses about sleep functions, which nevertheless remain elusive. In this review we discuss the specific contribution of both mammalian and invertebrate models to our understanding of the molecular basis of sleep.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev.genet.42.110807.091541