Surface-enhanced stereoselectivity in Mukaiyama aldol reactions catalyzed by clay-supported bis(oxazoline)-copper complexes

Surface effects on a laponite-exchanged bis(oxazoline)-copper complex modify the stereochemical course of the Mukaiyama aldol reaction between 2-(trimethylsilyloxy)furan and alpha-ketoesters, leading up to 90% ee (dr 86 : 14) becoming the best overall result obtained for this reaction and significan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2008-01 (42), p.5402-5404
Hauptverfasser:	Fabra, María J, Fraile, José M, Herrerías, Clara I, Lahoz, Fernando J, Mayoral, José A, Pérez, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemical synthesis Alcohols - chemistry Aluminum Silicates - chemistry Catalysis Copper - chemistry Cyclization Ketones - chemistry Models, Molecular Molecular Structure Organometallic Compounds - chemistry Oxazoles - chemistry Silicates - chemistry Stereoisomerism Surface Properties
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Surface effects on a laponite-exchanged bis(oxazoline)-copper complex modify the stereochemical course of the Mukaiyama aldol reaction between 2-(trimethylsilyloxy)furan and alpha-ketoesters, leading up to 90% ee (dr 86 : 14) becoming the best overall result obtained for this reaction and significantly improving the homogeneous process.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b809956a