Synthesis and Antiprotozoal Evaluation of New N4-(Benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones)

The synthesis and in‐vitro antiprotozoal evaluation of novel N4‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from N4‐(benzyl)spermidine is disclosed. Several of the new bis‐THTT have in‐vitro activities against L. donovani and T. cruzi that are comparable or supe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2008-11, Vol.341 (11), p.708-713
Hauptverfasser:	Coro, Julieta, Little, Susan, Yardley, Vanessa, Suárez, Margarita, Rodríguez, Hortensia, Martín, Nazario, Perez-Pineiro, Rolando
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,5‐Thiadiazinane‐2‐thione 5-Thiadiazinane-2-thione Animals Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - pharmacology Drug Evaluation, Preclinical Leishmania donovani Leishmania donovani - drug effects Protozoocidal activity Spermidine Spermidine - chemistry Structure-Activity Relationship Thiones - chemical synthesis Thiones - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The synthesis and in‐vitro antiprotozoal evaluation of novel N4‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from N4‐(benzyl)spermidine is disclosed. Several of the new bis‐THTT have in‐vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.
ISSN:	0365-6233 1521-4184
DOI:	10.1002/ardp.200800011