Balance of adiponectin and leptin modulates breast cancer cell growth

There is lack of information concerning how the ratio of adiponectin to leptin in serum affects breast cancer (Brca) proliferation. It is possible that the link between obesity and increased risk for aggressive Brca is in part due to the milieu of cytokines synthesized and released by the adipose ti...

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Veröffentlicht in:Cell research 2008-11, Vol.18 (11), p.1154-1156
Hauptverfasser: Grossmann, Michael E, Ray, Amitabha, Dogan, Soner, Mizuno, Nancy K, Cleary, Margot P
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Sprache:eng
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Zusammenfassung:There is lack of information concerning how the ratio of adiponectin to leptin in serum affects breast cancer (Brca) proliferation. It is possible that the link between obesity and increased risk for aggressive Brca is in part due to the milieu of cytokines synthesized and released by the adipose tissue [1]. Adiponectin (also known as adipocyte complement-related protein of 30 kDa (Acrp30)) and leptin are two specific cytokines secreted by the adipose tissue.
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2008.293