High numbers of clonal CD19+ cells in the peripheral blood of a patient with multiple myeloma

Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells w...

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Veröffentlicht in:	British journal of haematology 1999-04, Vol.105 (1), p.265-267
Hauptverfasser:	RASMUSSEN, T, KASTRUP, J, KNUDSEN, L. M, JOHNSEN, H. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD19 - metabolism B-Lymphocytes - pathology Biological and medical sciences Gene Rearrangement Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulin Heavy Chains - metabolism Immunoglobulinopathies Immunopathology Male Medical sciences Middle Aged Multiple Myeloma - pathology Reverse Transcriptase Polymerase Chain Reaction - methods
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Zusammenfassung:	Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of late-stage B cells or pre-plasma cells were present in the peripheral blood (PB) of a patient with MM. During treatment the initial high level of PB clonal cells was markedly reduced and remained low (
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1999.01301.x