Noduliprevenone: A Novel Heterodimeric Chromanone with Cancer Chemopreventive Potential

Impressive architecture, important activity! Noduliprevenone (shown here) is a unique marine fungal polyketide, incorporating two unusual chromanone subunits. The absolute configuration was assigned by using a combination of CD spectroscopy, NOE interactions and Mosher's method. Noduliprevenone...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry : a European journal 2008-11, Vol.14 (32), p.9860-9863
Hauptverfasser:	Pontius, Alexander, Krick, Anja, Kehraus, Stefan, Foegen, Silke E., Müller, Michael, Klimo, Karin, Gerhäuser, Clarissa, König, Gabriele M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascomycota - chemistry cancer chemoprevention Chromones - chemistry Chromones - pharmacology Circular Dichroism Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 CYP1A1 - drug effects Dose-Response Relationship, Drug heterodimeric chromanone Magnetic Resonance Spectroscopy medicinal chemistry Molecular Structure natural products Neoplasms - drug therapy Neoplasms - prevention & control structure elucidation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Impressive architecture, important activity! Noduliprevenone (shown here) is a unique marine fungal polyketide, incorporating two unusual chromanone subunits. The absolute configuration was assigned by using a combination of CD spectroscopy, NOE interactions and Mosher's method. Noduliprevenone was found to be an inhibitor of P450 (CYP1 A), and concomitantly induces NAD(P)H:quinone reductase (QR). This modulation of xenobiotic metabolism suggests noduliprevenone to be a cancer chemopreventive agent.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.200801574