Prostanoids and Related Compounds. VII. Synthesis and Inhibitory Activity of 1-Isoindolinone Derivatives Possessing Inhibitory Activity against Thromboxane A2 Analog (U-46619)-Induced Vasoconstriction

We have synthesized a series of novel 1-isoindolinone derivatives, which inhibited the contraction of pig coronary artery induced by U-46619, a thromboxane A2 analog.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1999/04/15, Vol.47(4), pp.529-535
Hauptverfasser: KATO, Yoshiaki, TAKEMOTO, Masumi, ACHIWA, Kazuo
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Sprache:eng
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Zusammenfassung:We have synthesized a series of novel 1-isoindolinone derivatives, which inhibited the contraction of pig coronary artery induced by U-46619, a thromboxane A2 analog.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.47.529