Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols

We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a γ-sulfone thiol. We have discovered a new series of potent MMP inhibitors that are selective for MMP-13 over MMP-1 incorporation a γ-sulfone thiol.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-04, Vol.9 (7), p.943-948
Hauptverfasser:	Freskos, John N., Mischke, Brent V., DeCrescenzo, Gary A., Heintz, Robert, Getman, Daniel P., Howard, Susan C., Kishore, Nandini N., McDonald, Joseph J., Munie, Grace E., Rangwala, Shaukat, Swearingen, Craig A., Voliva, Charles, Welsch, Dean J.
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumour compds Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Enzyme inhibitors Extracellular Matrix - enzymology Medical sciences Metalloendopeptidases - antagonists & inhibitors Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Sulfhydryl Compounds - chemical synthesis Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - pharmacology
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Beschreibung
Zusammenfassung:	We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a γ-sulfone thiol. We have discovered a new series of potent MMP inhibitors that are selective for MMP-13 over MMP-1 incorporation a γ-sulfone thiol.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00116-X