Metal-Free One-Pot Oxidative Amidation of Aldoses with Functionalized Amines

Metal-Free One-Pot Oxidative Amidation of Aldoses with Functionalized Amines

Metal-free one-pot oxidative amidation of aldoses with functionalized amines using iodine provides a rapid access to functionalized aldonamides. The main advantage of this approach relies on the fact that aldehyde oxidation and C−N bond formation are performed in a single synthetic operation.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2008-11, Vol.73 (21), p.8647-8650
Hauptverfasser: Colombeau, Ludovic, Traoré, Ténin, Compain, Philippe, Martin, Olivier R
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemical synthesis
Amines - chemistry
Carbohydrates - chemistry
Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Organic chemistry
Oxygen
Preparations and properties
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Beschreibung
Zusammenfassung:Metal-free one-pot oxidative amidation of aldoses with functionalized amines using iodine provides a rapid access to functionalized aldonamides. The main advantage of this approach relies on the fact that aldehyde oxidation and C−N bond formation are performed in a single synthetic operation.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo801626v